Telomeric replication stress: the beginning and the end for alternative lengthening of telomeres cancers.
ALT
alternative lengthening of telomeres
replication stress
telomere maintenance
Journal
Open biology
ISSN: 2046-2441
Titre abrégé: Open Biol
Pays: England
ID NLM: 101580419
Informations de publication
Date de publication:
03 2022
03 2022
Historique:
entrez:
9
3
2022
pubmed:
10
3
2022
medline:
3
5
2022
Statut:
ppublish
Résumé
Telomeres are nucleoprotein structures that cap the ends of linear chromosomes. Telomeric DNA comprises terminal tracts of G-rich tandem repeats, which are inherently difficult for the replication machinery to navigate. Structural aberrations that promote activation of the alternative lengthening of telomeres (ALT) pathway of telomere maintenance exacerbate replication stress at ALT telomeres, driving fork stalling and fork collapse. This form of telomeric DNA damage perpetuates recombination-mediated repair pathways and break-induced telomere synthesis. The relationship between replication stress and DNA repair is tightly coordinated for the purpose of regulating telomere length in ALT cells, but has been shown to be experimentally manipulatable. This raises the intriguing possibility that induction of replication stress can be used as a means to cause toxic levels of DNA damage at ALT telomeres, thereby selectively disrupting the viability of ALT cancers.
Identifiants
pubmed: 35259951
doi: 10.1098/rsob.220011
pmc: PMC8905155
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
220011Références
Proc Natl Acad Sci U S A. 2015 Dec 1;112(48):14864-9
pubmed: 26578802
J Cell Sci. 2004 May 1;117(Pt 11):2417-26
pubmed: 15126641
Cell. 1994 Aug 12;78(3):513-23
pubmed: 8062391
Genes Dev. 2019 Feb 1;33(3-4):221-235
pubmed: 30692206
Crit Rev Biochem Mol Biol. 2017 Dec;52(6):696-714
pubmed: 28954549
Cell Rep. 2021 Dec 7;37(10):110088
pubmed: 34879271
Cell Rep. 2013 Jun 27;3(6):1958-69
pubmed: 23746452
Cell. 2015 Feb 26;160(5):913-927
pubmed: 25723166
Oncogene. 2004 Jan 8;23(1):149-56
pubmed: 14712220
Elife. 2020 Mar 13;9:
pubmed: 32167469
DNA Repair (Amst). 2011 Oct 10;10(10):1034-43
pubmed: 21880555
Genes (Basel). 2020 Jun 10;11(6):
pubmed: 32532049
EMBO J. 2001 Oct 1;20(19):5532-40
pubmed: 11574485
Cell. 1997 Mar 7;88(5):657-66
pubmed: 9054505
J Biol Chem. 2018 Sep 14;293(37):14384-14392
pubmed: 30082315
Nat Genet. 2005 Sep;37(9):958-63
pubmed: 16116422
Mol Cell. 2010 Aug 27;39(4):606-17
pubmed: 20619712
Genes Dev. 2004 Jun 15;18(12):1391-6
pubmed: 15198981
Sci Rep. 2020 Oct 27;10(1):18411
pubmed: 33110104
Cell. 2011 Mar 4;144(5):646-74
pubmed: 21376230
Genes Dev. 1997 Nov 1;11(21):2801-9
pubmed: 9353250
Nature. 2012 Dec 13;492(7428):285-9
pubmed: 23103865
Front Cell Dev Biol. 2020 Jun 16;8:493
pubmed: 32612998
Cell Rep. 2016 Jun 7;15(10):2170-2184
pubmed: 27239034
Dev Cell. 2014 Apr 14;29(1):7-19
pubmed: 24735877
Mol Cell. 2018 Aug 16;71(4):510-525.e6
pubmed: 30033372
Trends Biochem Sci. 2015 Sep;40(9):504-15
pubmed: 26188776
Nature. 2012 Aug 23;488(7412):540-4
pubmed: 22763445
F1000Prime Rep. 2015 Mar 03;7:30
pubmed: 25926981
EMBO J. 2009 Mar 18;28(6):641-51
pubmed: 19197240
PLoS Genet. 2012;8(7):e1002772
pubmed: 22829774
Mol Cell. 2015 Feb 19;57(4):622-635
pubmed: 25620558
Nucleus. 2019 Dec;10(1):221-230
pubmed: 31663812
Mol Cell. 2017 Jan 19;65(2):247-259
pubmed: 27986371
Trends Cancer. 2020 Mar;6(3):247-260
pubmed: 32101727
EMBO Rep. 2016 Dec;17(12):1731-1737
pubmed: 27760777
Cell Rep. 2019 Jan 22;26(4):955-968.e3
pubmed: 30673617
DNA Repair (Amst). 2015 Jan;25:104-15
pubmed: 25467559
Cell Rep. 2020 Nov 10;33(6):108379
pubmed: 33176153
J Cell Biol. 2012 Dec 10;199(6):893-906
pubmed: 23229897
Oncotarget. 2015 Jun 30;6(18):16543-58
pubmed: 26001292
Mol Cell. 2009 Dec 25;36(6):943-53
pubmed: 20064461
Nucleic Acids Res. 1989 Jun 26;17(12):4611-27
pubmed: 2664709
Nat Struct Mol Biol. 2014 Feb;21(2):167-74
pubmed: 24413054
Cancer Res. 2003 Jun 15;63(12):3247-56
pubmed: 12810655
Nat Commun. 2015 Jul 06;6:7538
pubmed: 26143912
J Cell Biol. 2012 Apr 16;197(2):253-66
pubmed: 22508510
EMBO J. 2013 Oct 30;32(21):2861-71
pubmed: 24084588
Nucleic Acids Res. 2014 Apr;42(7):4391-405
pubmed: 24500201
Nat Commun. 2019 May 28;10(1):2252
pubmed: 31138797
EMBO J. 1995 Sep 1;14(17):4240-8
pubmed: 7556065
Nat Rev Genet. 2012 Nov;13(11):770-80
pubmed: 23032257
Sci Adv. 2019 May 08;5(5):eaav3673
pubmed: 31086817
Nat Struct Mol Biol. 2018 Feb;25(2):147-153
pubmed: 29358759
RNA Biol. 2018;15(7):868-876
pubmed: 29902117
Cell. 2009 Jan 9;136(1):175-86
pubmed: 19135898
Semin Cell Dev Biol. 2010 Apr;21(2):186-93
pubmed: 19815087
Nature. 2007 Aug 30;448(7157):1068-71
pubmed: 17687332
Nat Commun. 2021 Jun 18;12(1):3760
pubmed: 34145295
Cell Rep. 2016 Feb 9;14(5):1032-1040
pubmed: 26832416
Exp Cell Res. 1965 Mar;37:614-36
pubmed: 14315085
J Cell Biol. 2015 Jan 19;208(2):147-60
pubmed: 25601401
Science. 2004 Dec 10;306(5703):1951-3
pubmed: 15591207
Nat Commun. 2019 May 28;10(1):2253
pubmed: 31138795
EMBO J. 1995 Nov 1;14(21):5433-43
pubmed: 7489732
Mol Cell Biol. 2000 Dec;20(23):9028-40
pubmed: 11074001
Genes Cells. 2008 Oct;13(10):1045-59
pubmed: 18761675
Nat Genet. 2002 Mar;30(3):301-5
pubmed: 11919561
EMBO J. 2021 Jun 15;40(12):e107346
pubmed: 33934394
Cell. 2009 Jul 10;138(1):90-103
pubmed: 19596237
Mech Ageing Dev. 2019 Jan;177:37-45
pubmed: 29604323
Nat Commun. 2013;4:1423
pubmed: 23361013
Carcinogenesis. 2010 Jun;31(6):994-1002
pubmed: 20130019
Cell Death Dis. 2016 May 12;7:e2220
pubmed: 27171262
Nature. 2011 Mar 24;471(7339):532-6
pubmed: 21399625
Trends Cell Biol. 2015 Jan;25(1):29-36
pubmed: 25257515
Sci Adv. 2019 Oct 09;5(10):eaax6366
pubmed: 31633027
PLoS Genet. 2017 Dec 27;13(12):e1007119
pubmed: 29281621
Nat Struct Mol Biol. 2009 Dec;16(12):1244-51
pubmed: 19935685
Am J Pathol. 2011 Oct;179(4):1608-15
pubmed: 21888887
Genes Dev. 2009 Sep 1;23(17):2060-75
pubmed: 19679647
Oncogene. 2002 Jan 21;21(4):532-40
pubmed: 11850778
DNA Repair (Amst). 2013 Feb 1;12(2):128-39
pubmed: 23253856
Nat Struct Mol Biol. 2017 Sep;24(9):734-742
pubmed: 28805810
Annu Rev Genet. 2008;42:301-34
pubmed: 18680434
Cell. 2013 Oct 10;155(2):345-356
pubmed: 24120135
Science. 1995 Dec 8;270(5242):1663-7
pubmed: 7502076
Subcell Biochem. 2012;62:157-69
pubmed: 22918585
Cell Mol Life Sci. 2002 Aug;59(8):1317-26
pubmed: 12363035
Cell. 2012 Jul 6;150(1):39-52
pubmed: 22748632
EMBO J. 2010 Mar 3;29(5):924-33
pubmed: 20094033
Nucleic Acids Res. 2014 Feb;42(3):1733-46
pubmed: 24225324
Genes Dev. 2019 Jul 1;33(13-14):814-827
pubmed: 31171703
Oncotarget. 2018 Mar 23;9(22):15836-15846
pubmed: 29662610
Elife. 2020 Jan 14;9:
pubmed: 31934863
Nature. 2016 Nov 3;539(7627):54-58
pubmed: 27760120
Genes Dev. 2020 Dec 1;34(23-24):1619-1636
pubmed: 33122293
Nat Commun. 2014 Oct 21;5:5220
pubmed: 25330849
Nat Commun. 2018 Jul 18;9(1):2791
pubmed: 30022024
Nature. 2015 May 28;521(7553):537-540
pubmed: 25799990
PLoS Genet. 2010 Apr 22;6(4):e1000920
pubmed: 20421929
Eur J Cancer. 2021 Jul;151:136-149
pubmed: 33984662
J Biol Chem. 2009 Feb 13;284(7):4041-5
pubmed: 18835809
Science. 1995 Sep 15;269(5230):1533-4
pubmed: 7545310
Sci Rep. 2016 Aug 31;6:32280
pubmed: 27578458
Science. 2015 Jan 16;347(6219):273-7
pubmed: 25593184
Cell Cycle. 2005 Apr;4(4):585-9
pubmed: 15753647
Nat Struct Mol Biol. 2014 Sep;21(9):760-70
pubmed: 25150861
EMBO J. 2014 Nov 3;33(21):2521-33
pubmed: 25193968
Mol Cell Biochem. 2016 Jan;412(1-2):165-71
pubmed: 26708217
Proc Natl Acad Sci U S A. 2017 Jul 18;114(29):E5940-E5949
pubmed: 28673972
Proc Natl Acad Sci U S A. 2010 Aug 10;107(32):14075-80
pubmed: 20651253
Cell Rep. 2017 Jan 17;18(3):611-623
pubmed: 27986592
J Gerontol A Biol Sci Med Sci. 2000 Nov;55(11):B533-6
pubmed: 11078086
PLoS Biol. 2020 Jan 2;18(1):e3000594
pubmed: 31895940
Genes Dev. 2012 Jun 1;26(11):1167-78
pubmed: 22661228
Science. 2007 Nov 2;318(5851):798-801
pubmed: 17916692
Blood. 2006 Sep 15;108(6):2072-80
pubmed: 16720839
Cell Rep. 2015 Nov 24;13(8):1633-46
pubmed: 26586433
RNA. 2019 Mar;25(3):352-363
pubmed: 30538148
Mol Cell Biol. 2005 Jan;25(2):808-18
pubmed: 15632080
EMBO J. 2017 Oct 2;36(19):2907-2919
pubmed: 28877996
Proc Natl Acad Sci U S A. 2008 Jun 10;105(23):8073-8
pubmed: 18523010
Mol Cell. 2005 Apr 1;18(1):131-8
pubmed: 15808515
Cell. 1999 May 14;97(4):503-14
pubmed: 10338214
J Biol Chem. 2001 Jun 15;276(24):21209-16
pubmed: 11399775
Proc Natl Acad Sci U S A. 1989 Sep;86(18):7049-53
pubmed: 2780561
Cancers (Basel). 2021 May 14;13(10):
pubmed: 34069193
Cell. 2012 Aug 3;150(3):481-94
pubmed: 22863003
Genes (Basel). 2017 Mar 28;8(4):
pubmed: 28350373
Mol Cell Biol. 2017 Sep 26;37(20):
pubmed: 28760773
Mol Cell. 2019 Jul 11;75(1):117-130.e6
pubmed: 31101499
Genes Dev. 2014 Nov 15;28(22):2477-91
pubmed: 25344324
Blood. 2009 Jul 2;114(1):174-80
pubmed: 19423727
Biochemistry. 2001 Dec 18;40(50):15194-202
pubmed: 11735402
Sci Rep. 2015 Sep 02;5:13693
pubmed: 26329134
Biochim Biophys Acta Mol Cell Res. 2017 Jan;1864(1):191-201
pubmed: 27836746
Mol Cell. 2016 Dec 15;64(6):1117-1126
pubmed: 27984745
Hum Mol Genet. 2012 May 1;21(9):2005-16
pubmed: 22279085
Proc Natl Acad Sci U S A. 2011 Apr 19;108(16):6492-6
pubmed: 21464321
Nat Struct Mol Biol. 2013 Oct;20(10):1199-205
pubmed: 24013207
Nat Cell Biol. 2014 Jan;16(1):2-9
pubmed: 24366029
PLoS One. 2012;7(11):e50062
pubmed: 23185534
Exp Cell Res. 1961 Dec;25:585-621
pubmed: 13905658
Atherosclerosis. 2003 Nov;171(1):57-65
pubmed: 14642406
Cell. 2014 Sep 25;159(1):108-121
pubmed: 25259924
Sci Rep. 2019 Dec 13;9(1):19110
pubmed: 31836759
Hum Mol Genet. 2008 Jun 1;17(11):1641-52
pubmed: 18285517
Annu Rev Biochem. 2004;73:177-208
pubmed: 15189140
Nature. 2019 Nov;575(7783):523-527
pubmed: 31723267
Br J Cancer. 2007 Apr 10;96(7):1020-4
pubmed: 17353922
Org Biomol Chem. 2012 Aug 28;10(32):6537-46
pubmed: 22790277
PLoS One. 2014 Oct 29;9(10):e110963
pubmed: 25354277
Annu Rev Genet. 2018 Nov 23;52:223-247
pubmed: 30208292
Nature. 1990 May 31;345(6274):458-60
pubmed: 2342578