α-Parvin Defines a Specific Integrin Adhesome to Maintain the Glomerular Filtration Barrier.
IPP complex
PARVA
PARVB
focal adhesion
focal segmental glomerulosclerosis
glomerular epithelial cells
glomerular filtration barrier
integrin adhesion complex
podocyte
proteinuria
Journal
Journal of the American Society of Nephrology : JASN
ISSN: 1533-3450
Titre abrégé: J Am Soc Nephrol
Pays: United States
ID NLM: 9013836
Informations de publication
Date de publication:
04 2022
04 2022
Historique:
received:
10
08
2021
accepted:
17
01
2022
pubmed:
10
3
2022
medline:
5
4
2022
entrez:
9
3
2022
Statut:
ppublish
Résumé
The cell-matrix adhesion between podocytes and the glomerular basement membrane is essential for the integrity of the kidney's filtration barrier. Despite increasing knowledge about the complexity of integrin adhesion complexes, an understanding of the regulation of these protein complexes in glomerular disease remains elusive. We mapped the We found that The findings reveal adaptive mechanisms of podocyte integrin adhesion complexes, providing a conceptual framework for therapeutic strategies to prevent podocyte detachment in glomerular disease.
Sections du résumé
BACKGROUND
The cell-matrix adhesion between podocytes and the glomerular basement membrane is essential for the integrity of the kidney's filtration barrier. Despite increasing knowledge about the complexity of integrin adhesion complexes, an understanding of the regulation of these protein complexes in glomerular disease remains elusive.
METHODS
We mapped the
RESULTS
We found that
CONCLUSIONS
The findings reveal adaptive mechanisms of podocyte integrin adhesion complexes, providing a conceptual framework for therapeutic strategies to prevent podocyte detachment in glomerular disease.
Identifiants
pubmed: 35260418
pii: 00001751-202204000-00014
doi: 10.1681/ASN.2021101319
pmc: PMC8970443
doi:
Substances chimiques
Integrins
0
Microfilament Proteins
0
Parva protein, mouse
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
786-808Informations de copyright
Copyright © 2022 by the American Society of Nephrology.
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