PET/MRI-evaluated brown adipose tissue activity may be related to dietary MUFA and omega-6 fatty acids intake.


Journal

Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288

Informations de publication

Date de publication:
08 03 2022
Historique:
received: 19 11 2021
accepted: 03 03 2022
entrez: 9 3 2022
pubmed: 10 3 2022
medline: 22 4 2022
Statut: epublish

Résumé

An investigation of new ways to activate brown adipose tissue (BAT) is highly valuable, as it is a possible tool for obesity prevention and treatment. The aim of our study was to evaluate the relationships between dietary intake and BAT activity. The study group comprised 28 healthy non-smoking males aged 21-42 years. All volunteers underwent a physical examination and 75-g OGTT and completed 3-day food intake diaries to evaluate macronutrients and fatty acid intake. Body composition measurements were assessed using DXA scanning. An FDG-18 PET/MR was performed to visualize BAT activity. Brown adipose tissue was detected in 18 subjects (67% normal-weight individuals and 33% overweight/obese). The presence of BAT corresponded with a lower visceral adipose tissue (VAT) content (p = 0.04, after adjustment for age, daily kcal intake, and DXA Lean mass). We noted significantly lower omega-6 fatty acids (p = 0.03) and MUFA (p = 0.02) intake in subjects with detected BAT activity after adjustment for age, daily average kcal intake, and DXA Lean mass, whereas omega-3 fatty acids intake was comparable between the two groups. BAT presence was positively associated with the concentration of serum IL-6 (p = 0.01) during cold exposure. Our results show that BAT activity may be related to daily omega-6 fatty acids intake.

Identifiants

pubmed: 35260768
doi: 10.1038/s41598-022-08125-z
pii: 10.1038/s41598-022-08125-z
pmc: PMC8904502
doi:

Substances chimiques

Fatty Acids, Omega-6 0
Fluorodeoxyglucose F18 0Z5B2CJX4D

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

4112

Informations de copyright

© 2022. The Author(s).

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Auteurs

Katarzyna Maliszewska (K)

Department of Endocrinology, Diabetology and Internal Medicine, Medical University of Bialystok, M. Sklodowskiej-Curie24A, Bialystok, Poland. maliszewska.k@gmail.com.

Edyta Adamska-Patruno (E)

Clinical Research Centre, Medical University of Bialystok, M. Sklodowskiej-Curie24A, Bialystok, Poland. edyta.adamska@umb.edu.pl.

K Miniewska (K)

Clinical Research Centre, Medical University of Bialystok, M. Sklodowskiej-Curie24A, Bialystok, Poland.

W Bauer (W)

Clinical Research Centre, Medical University of Bialystok, M. Sklodowskiej-Curie24A, Bialystok, Poland.

M Mojsak (M)

Independent Laboratory of Molecular Imaging, Medical University of Bialystok, ul. Żurawia 71A, 15-540, Bialystok, Poland.

A Kretowski (A)

Department of Endocrinology, Diabetology and Internal Medicine, Medical University of Bialystok, M. Sklodowskiej-Curie24A, Bialystok, Poland.

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