Quantitative trait loci, G×E and G×G for glycemic traits: response to metformin and placebo in the Diabetes Prevention Program (DPP).

Blood Glucose / genetics Diabetes Mellitus, Type 2 / drug therapy Humans Insulin / genetics Metformin / therapeutic use Polymorphism, Single Nucleotide Quantitative Trait Loci / genetics

Journal

Journal of human genetics
ISSN: 1435-232X
Titre abrégé: J Hum Genet
Pays: England
ID NLM: 9808008

Informations de publication

Date de publication:
Aug 2022
Historique:
received: 09 09 2021
accepted: 17 02 2022
revised: 16 02 2022
pubmed: 10 3 2022
medline: 27 7 2022
entrez: 9 3 2022
Statut: ppublish

Résumé

The complex genetic architecture of type-2-diabetes (T2D) includes gene-by-environment (G×E) and gene-by-gene (G×G) interactions. To identify G×E and G×G, we screened markers for patterns indicative of interactions (relationship loci [rQTL] and variance heterogeneity loci [vQTL]). rQTL exist when the correlation between multiple traits varies by genotype and vQTL occur when the variance of a trait differs by genotype (potentially flagging G×G and G×E). In the metformin and placebo arms of the DPP (n = 1762) we screened 280,965 exomic and intergenic SNPs, for rQTL and vQTL patterns in association with year one changes from baseline in glycemia and related traits (insulinogenic index [IGI], insulin sensitivity index [ISI], fasting glucose and fasting insulin). Significant (p < 1.8 × 10

Identifiants

DOI: 10.1038/s10038-022-01027-y PMID: 35260800 PMC: PMC10102970
pubmed: 35260800
doi: 10.1038/s10038-022-01027-y
pii: 10.1038/s10038-022-01027-y
pmc: PMC10102970
mid: NIHMS1883494
doi:

Substances chimiques

Blood Glucose 0
Insulin 0
Metformin 9100L32L2N

Types de publication

Journal Article Randomized Controlled Trial

Langues

eng

Sous-ensembles de citation

IM

Pagination

465-473

Subventions

Organisme : NIDDK NIH HHS
ID : U01 DK048412
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK048375
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK048434
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK048413
Pays : United States
Organisme : NCRR NIH HHS
ID : M01 RR016587
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK048339
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK048468
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK048387
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK048404
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK048377
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK048407
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK048437
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK048406
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK048397
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK048381
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK048514
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK048485
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK048411
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK048443
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK048380
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK048400
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK048489
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK048349
Pays : United States

Commentaires et corrections

Type : ErratumIn

Informations de copyright

© 2022. The Author(s), under exclusive licence to The Japan Society of Human Genetics.

Références

BMC Med Genet. 2007 Sep 19;8 Suppl 1:S14
pubmed: 17903296
Genet Epidemiol. 2011 Nov;35(7):729-38
pubmed: 21922538
Genet Epidemiol. 2013 Sep;37(6):603-13
pubmed: 23873611
Arterioscler Thromb Vasc Biol. 2014 Jan;34(1):99-109
pubmed: 24177325
BMC Genet. 2012 Jul 24;13:63
pubmed: 22827487
Nature. 2014 Apr 10;508(7495):249-53
pubmed: 24572353
PLoS Genet. 2012;8(8):e1002839
pubmed: 22876191
N Engl J Med. 2002 Feb 7;346(6):393-403
pubmed: 11832527
Sci Adv. 2019 Aug 14;5(8):eaaw3538
pubmed: 31453325
PLoS One. 2011 May 12;6(5):e19416
pubmed: 21589913
Evolution. 1997 Oct;51(5):1654-1662
pubmed: 28568634
BMC Med Genet. 2007 Sep 19;8 Suppl 1:S18
pubmed: 17903300
Proc Biol Sci. 2011 Jun 22;278(1713):1903-12
pubmed: 21106581
PLoS Genet. 2010 Jun 17;6(6):e1000981
pubmed: 20585554
Genet Epidemiol. 2008 Apr;32(3):255-63
pubmed: 18200600
Genetics. 1995 Mar;139(3):1455-61
pubmed: 7768453
Ann Hum Genet. 2004 Nov;68(Pt 6):521-35
pubmed: 15598211
Nat Genet. 2008 Aug;40(8):955-62
pubmed: 18587394
Alzheimers Res Ther. 2018 Aug 28;10(1):86
pubmed: 30153862
BMC Med Genet. 2007 Sep 19;8 Suppl 1:S10
pubmed: 17903292
J Exp Zool B Mol Dev Evol. 2011 Jul 15;316(5):371-85
pubmed: 21462316
Genet Epidemiol. 2014 Jan;38(1):51-59
pubmed: 24482837
Genet Epidemiol. 2012 Apr;36(3):183-94
pubmed: 22714933
Proc Natl Acad Sci U S A. 2008 Dec 16;105(50):19910-4
pubmed: 19066216
Ann Hum Genet. 2011 Jan;75(1):36-45
pubmed: 20384625
Evolution. 2008 Jan;62(1):199-213
pubmed: 18005158
Heredity (Edinb). 2010 Apr;104(4):401-9
pubmed: 19789566
BMC Genet. 2010 Oct 13;11:92
pubmed: 20942902
Genetics. 2013 Dec;195(4):1397-405
pubmed: 24097412
Curr Opin Genet Dev. 2004 Jun;14(3):253-7
pubmed: 15172667
Biometrika. 2012 Dec;99(4):929-944
pubmed: 23843674

Auteurs

Taylor J Maxwell (TJ)

Computational Biology Institute, The George Washington University, Ashburn, VA, USA. tmaxwell@gwu.edu.

Paul W Franks (PW)

Genetic & Molecular Epidemiology Unit, Lund University Diabetes Center, Lund, Sweden.

Steven E Kahn (SE)

VA Puget Sound Health Care System and University of Washington, Seattle, WA, USA.

William C Knowler (WC)

National Institute of Diabetes and Digestive and Kidney Diseases, Phoenix, AZ, USA.

Kieren J Mather (KJ)

Center for Diabetes and Metabolic Diseases & Division of Endocrinology & Metabolism, Indiana University School of Medicine, Indianapolis, IN, USA.

Jose C Florez (JC)

Diabetes Unit and Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.
Programs in Metabolism and Medical & Population Genetics, Broad Institute, Cambridge, MA, USA.
Department of Medicine, Harvard Medical School, Boston, MA, USA.

Kathleen A Jablonski (KA)

The Biostatistics Center, The Milken Institute of Public Health, The George Washington University, Rockville, MD, USA.

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Classifications MeSH

questionsmedicales.fr › Glucides › Sucres › Oses › Hexose › Glucose › Glycémie › Quantitative trait loci, G×E and G×G for...
questionsmedicales.fr › Maladies endocriniennes › Diabète › Diabète de type 2 › Quantitative trait loci, G×E and G×G for...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Quantitative trait loci, G×E and G×G for...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Hormones peptidiques › Hormones pancréatiques › Insulines › Insuline › Quantitative trait loci, G×E and G×G for...
questionsmedicales.fr › Composés chimiques organiques › Amidines › Guanidines › Biguanides › Metformine › Quantitative trait loci, G×E and G×G for...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Polymorphisme génétique › Polymorphisme de nucléotide simple › Quantitative trait loci, G×E and G×G for...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Locus génétiques › Locus de caractère quantitatif › Quantitative trait loci, G×E and G×G for...