Prenatal exposure to pesticide residues in the diet in association with child autism-related traits: Results from the EARLI study.
autism spectrum disorder
autism-related traits
fruit
pesticide residues
prenatal diet
vegetables
Journal
Autism research : official journal of the International Society for Autism Research
ISSN: 1939-3806
Titre abrégé: Autism Res
Pays: United States
ID NLM: 101461858
Informations de publication
Date de publication:
05 2022
05 2022
Historique:
revised:
22
02
2022
received:
05
11
2021
accepted:
23
02
2022
pubmed:
10
3
2022
medline:
14
5
2022
entrez:
9
3
2022
Statut:
ppublish
Résumé
Prior work has suggested associations between prenatal exposure to several classes of pesticides and child autism spectrum disorder (ASD). We examined a previously developed pesticide residue burden score (PRBS) and intake of high pesticide residue foods in association with ASD-related traits. Participants were drawn from the Early Autism Risk Longitudinal Investigation (EARLI) (n = 256), a cohort following mothers who previously had a child with ASD through a subsequent pregnancy and that child's development. ASD-related traits were captured according to total Social Responsiveness Scale (SRS) scores at age 3 (mean raw total SRS score = 35.8). Dietary intake was assessed through a food frequency questionnaire collected during pregnancy. We also incorporated organic intake and fatty foods in modified versions of the PRBS. Associations between high-residue fruit and vegetable intake, the overall PRBS and modified versions of it, and SRS scores were assessed using multivariable linear regression. Overall, we did not observe associations between pesticide residues in foods and ASD-related outcomes, and modified versions of the PRBS yielded similar findings. However, reductions in ASD-related traits were observed with higher overall fruit and vegetable intake (adjusted estimates for Q4 vs. Q1: β -12.76, 95%CI -27.8, 2.3). Thus, findings from this high familial probability cohort did not suggest relationships between pesticide residues in the diet according to the PRBS and ASD-related traits. Beneficial effects of fruit and vegetable intake may influence these relationships. Future work should consider fruit and vegetable intake in association with ASD-related outcomes. LAY SUMMARY: Diet is the main source of exposure to most pesticides in use today. In this study, we examined the relationship between pesticide exposure from residues in the diet during pregnancy and child autism-related traits. We found that these pesticide residues from the diet were not related to child autism-related outcomes at age three. However, higher prenatal fruit and vegetable intake was associated with reductions in child autism-related traits.
Identifiants
pubmed: 35261202
doi: 10.1002/aur.2698
pmc: PMC9090949
mid: NIHMS1784329
doi:
Substances chimiques
Pesticide Residues
0
Pesticides
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
957-970Subventions
Organisme : Autism Speaks
ID : AS5938
Pays : United States
Organisme : Autism Speaks
ID : AS5938
Pays : United States
Organisme : NIEHS NIH HHS
ID : P30 ES000002
Pays : United States
Organisme : NIEHS NIH HHS
ID : U24 ES028533
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK046200
Pays : United States
Organisme : NIEHS NIH HHS
ID : R01 ES016443
Pays : United States
Organisme : NIEHS NIH HHS
ID : R24 ES028533
Pays : United States
Informations de copyright
© 2022 The Authors. Autism Research published by International Society for Autism Research and Wiley Periodicals LLC.
Références
Chemosphere. 2006 Aug;64(9):1507-13
pubmed: 16466768
Autism Res. 2022 May;15(5):957-970
pubmed: 35261202
Am J Clin Nutr. 2012 Jul;96(1):80-9
pubmed: 22648721
Environ Health Perspect. 2014 May;122(5):513-20
pubmed: 24622245
Annu Rev Public Health. 2017 Mar 20;38:81-102
pubmed: 28068486
Am J Psychiatry. 2014 Nov 1;171(11):1206-13
pubmed: 24969362
Environ Res. 2021 Mar;194:110495
pubmed: 33220244
Environ Res. 2014 Feb;129:47-51
pubmed: 24529002
Int J Environ Res Public Health. 2012 Aug;9(8):2964-85
pubmed: 23066409
Environ Int. 2018 Oct;119:421-428
pubmed: 30029096
JAMA Intern Med. 2018 Jan 1;178(1):17-26
pubmed: 29084307
J Autism Dev Disord. 2015 Mar;45(3):719-30
pubmed: 25178989
Am J Epidemiol. 2016 Feb 1;183(3):169-82
pubmed: 26740026
Pharmacol Rep. 2017 Dec;69(6):1232-1239
pubmed: 29128804
Am J Psychiatry. 2006 Feb;163(2):294-6
pubmed: 16449484
J Nutr. 2016 May;146(5):1084-92
pubmed: 27075904
Environ Res. 2017 Aug;157:9-16
pubmed: 28501654
Autism Res. 2010 Feb;3(1):30-9
pubmed: 20143326
Curr Opin Pediatr. 2008 Apr;20(2):198-204
pubmed: 18332718
J Autism Dev Disord. 2021 Mar;51(3):839-848
pubmed: 31939081
Front Synaptic Neurosci. 2010 Sep 08;2:136
pubmed: 21423522
Environ Health. 2017 Oct 27;16(1):111
pubmed: 29073935
Int J Androl. 2010 Apr;33(2):443-62
pubmed: 20487044
Environ Int. 2015 Dec;85:206-12
pubmed: 26414943
Sci Total Environ. 2017 Jul 15;590-591:655-662
pubmed: 28284640
Epidemiology. 2017 Oct;28 Suppl 1:S35-S40
pubmed: 29028673
Environ Health Perspect. 2018 Apr 25;126(4):047012
pubmed: 29701446
Environ Health Perspect. 2017 Sep 08;125(9):097007
pubmed: 28934093
Am J Psychiatry. 2018 Nov 1;175(11):1094-1101
pubmed: 30111184
Environ Int. 2018 Apr;113:231-239
pubmed: 29453090
Chemosphere. 2013 Feb;90(5):1704-10
pubmed: 23141556
Environ Health Perspect. 2007 Dec;115 Suppl 1:98-105
pubmed: 18174957
Curr Opin Pediatr. 2008 Apr;20(2):191-7
pubmed: 18332717
J Autism Dev Disord. 2003 Aug;33(4):427-33
pubmed: 12959421
Autism Res. 2017 Apr;10(4):585-592
pubmed: 27739255
Am J Intellect Dev Disabil. 2011 Sep;116(5):331-43
pubmed: 21905802
Am J Psychiatry. 2000 Dec;157(12):2043-5
pubmed: 11097975
Epidemiology. 2019 May;30(3):418-426
pubmed: 30789431
Environ Health Perspect. 2016 Jun;124(6):822-30
pubmed: 26418669
Thyroid. 2003 Feb;13(2):193-8
pubmed: 12699594
Environ Health Perspect. 2014 Oct;122(10):1103-9
pubmed: 24954055
Interdiscip Toxicol. 2016 Dec;9(3-4):90-100
pubmed: 28652852
Pediatrics. 2015 Oct;136 Suppl 1:S41-59
pubmed: 26430169
Arch Gen Psychiatry. 2011 Nov;68(11):1095-102
pubmed: 21727249
Curr Opin Pediatr. 2011 Dec;23(6):609-15
pubmed: 21970828
Neurotoxicology. 2018 Dec;69:201-208
pubmed: 29203293
MMWR Surveill Summ. 2018 Nov 16;65(13):1-23
pubmed: 30439868
Am J Epidemiol. 2013 Jul 15;178(2):209-20
pubmed: 23813699
Pediatrics. 2006 Jul;118(1):233-41
pubmed: 16818570
Environ Health Perspect. 2011 Aug;119(8):1189-95
pubmed: 21507776
Environ Int. 2013 Sep;59:225-31
pubmed: 23845936
Br J Nutr. 2015 Sep 14;114(5):663-72
pubmed: 26243379
Am J Clin Nutr. 2002 Dec;76(6):1261-71
pubmed: 12450892
Environ Health Perspect. 2007 May;115(5):792-8
pubmed: 17520070
Environ Health Perspect. 2003 Nov;111(14):1779-82
pubmed: 14594631
Proc Natl Acad Sci U S A. 2012 May 15;109(20):7871-6
pubmed: 22547821
Environ Int. 2014 Sep;70:125-31
pubmed: 24934853
Environ Health. 2012 Nov 09;11:83
pubmed: 23140444
Pediatrics. 2010 Jun;125(6):e1270-7
pubmed: 20478945
Toxicol Sci. 2006 Sep;93(1):125-35
pubmed: 16790487
Environ Int. 2016 Jul-Aug;92-93:294-300
pubmed: 27128714
Am J Epidemiol. 1985 Jul;122(1):51-65
pubmed: 4014201
Autism. 2021 Oct;25(7):2112-2123
pubmed: 33962531
J Neurodev Disord. 2012 Apr 18;4(1):7
pubmed: 22958474
Paediatr Perinat Epidemiol. 2016 Sep;30(5):479-87
pubmed: 27239935
Child Neuropsychol. 2016;22(5):556-69
pubmed: 25833070
Biol Psychiatry. 2005 Mar 15;57(6):655-60
pubmed: 15780853
Am J Epidemiol. 2001 Dec 15;154(12):1089-99
pubmed: 11744511
Am J Epidemiol. 2018 Nov 1;187(11):2292-2296
pubmed: 30099488
J Expo Sci Environ Epidemiol. 2018 Jan;28(1):31-39
pubmed: 28930298
Environ Res. 2005 Feb;97(2):170-7
pubmed: 15533333
Toxicol Sci. 2006 Jul;92(1):235-45
pubmed: 16611628
Am J Epidemiol. 1992 May 15;135(10):1114-26; discussion 1127-36
pubmed: 1632423
J Abnorm Psychol. 2021 Aug;130(6):665-675
pubmed: 34553961
Environ Health Perspect. 2017 Mar;125(3):474-480
pubmed: 27548254
Environ Res. 2016 Apr;146:136-44
pubmed: 26749444
Arch Gen Psychiatry. 2003 May;60(5):524-30
pubmed: 12742874
J Neuroinflammation. 2016 Jun 14;13(1):149
pubmed: 27301868
Neurotoxicology. 2017 Sep;62:231-238
pubmed: 28811173
Environ Int. 2014 Dec;73:304-11
pubmed: 25192887
Environ Health Perspect. 2009 Mar;117(3):348-53
pubmed: 19337507
Environ Health Perspect. 2011 Jun;119(6):878-85
pubmed: 21233055
BMJ. 2019 Mar 20;364:l962
pubmed: 30894343
Dev Psychopathol. 2009 Winter;21(1):127-38
pubmed: 19144226
Ann Epidemiol. 2004 Nov;14(10):754-62
pubmed: 15519898
Environ Health Perspect. 2007 Oct;115(10):1482-9
pubmed: 17938740
Int J Hyg Environ Health. 2018 Apr;221(3):548-555
pubmed: 29478806
Paediatr Child Health. 2019 Nov;24(7):424-443
pubmed: 31660041
Environ Health Perspect. 2009 Mar;117(3):488-94
pubmed: 19337527
Curr Opin Neurol. 2010 Apr;23(2):111-7
pubmed: 20160651