Cross-Communication Between Knee Osteoarthritis and Fibrosis: Molecular Pathways and Key Molecules.
fibrosis
knee
molecules
osteoarthritis
Journal
Open access journal of sports medicine
ISSN: 1179-1543
Titre abrégé: Open Access J Sports Med
Pays: New Zealand
ID NLM: 101566036
Informations de publication
Date de publication:
2022
2022
Historique:
received:
10
11
2021
accepted:
18
02
2022
entrez:
9
3
2022
pubmed:
10
3
2022
medline:
10
3
2022
Statut:
epublish
Résumé
Knee fibrosis is characterized by the presence of excessive connective tissue due to dysregulated fibroblast activation following local or systemic tissue damage. Knee fibrosis constitutes a major clinical problem in orthopaedics due to the severe limitation in the knee range of motion that leads to compromised function and patient disability. Knee osteoarthritis is an extremely common orthopedic condition that is associated with patient disability and major costs to the health-care systems worldwide. Although knee fibrosis and osteoarthritis (OA) have traditionally been perceived as two separate pathologic entities, recent research has shown common ground between the pathophysiologic processes that lead to the development of these two conditions. The purpose of this review was to identify the pathophysiologic pathways as well as key molecules that are implicated in the development of both knee OA and knee fibrosis in order to understand the relationship between the two diagnoses and potentially identify novel therapeutic targets.
Identifiants
pubmed: 35261547
doi: 10.2147/OAJSM.S321139
pii: 321139
pmc: PMC8898188
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
1-15Subventions
Organisme : NIA NIH HHS
ID : R01 AG058624
Pays : United States
Organisme : NIAMS NIH HHS
ID : R01 AR071734
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001855
Pays : United States
Informations de copyright
© 2022 Bolia et al.
Déclaration de conflit d'intérêts
Dr Frank A Petrigliano reports IP royalties, Paid presenter or speaker from Exactech, Inc, Paid presenter or speaker from Stryker, outside the submitted work.
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