A Comparative Study of Chemical Profiling and Biological Effects of Doronicum orientale Extracts.
Doronicum orientale
HPLC/MS/MS
antioxidants
caffeoylquinic acids
enzyme inhibitors
Journal
Chemistry & biodiversity
ISSN: 1612-1880
Titre abrégé: Chem Biodivers
Pays: Switzerland
ID NLM: 101197449
Informations de publication
Date de publication:
Apr 2022
Apr 2022
Historique:
received:
27
01
2022
accepted:
08
03
2022
pubmed:
10
3
2022
medline:
23
4
2022
entrez:
9
3
2022
Statut:
ppublish
Résumé
In this study, phytochemical and pharmacological screening of the aerial part and roots extracts from Doronicum orientale Hoffm. (Asteraceae) was carried out. Plant extracts were obtained using solvents of different polarity (hexane, ethyl acetate, ethanol, ethanol/water, water) for selection the most optimal solvent for the extraction of active compounds. For instance, the extracts yielded total phenolic and flavonoid contents in the range of 12.13-45.67 mg GAE/g and 0.75-12.44 mg QE/g, respectively, while the total antioxidant capacity of the extracts determined by the phosphomolybdenum assay ranged from 0.88-2.53 mmol TE/g. HPLC/MS/MS analysis revealed 5-caffeoylquinic acid (2.52-337.05 μg/g) and 3,5-dicaffeoylquinic acid (3.12-299.36 μg/g) to be the major components present in the investigated extracts. Antioxidant activity in terms of radical scavenging ability of the extracts ranged from 0.82-45.56 mg TE/g in DPPH assay and from 5.07-104.58 mg TE/g in ABTS assay. The tested extracts were found to inhibit acetylcholinesterase (aerial part: 0.50-2.33 mg GALAE/g; roots: 0.40-2.43 mg GALAE/g), while with the exception of the water extracts, the other extracts showed butyrylcholinesterase inhibition (aerial part: 2.46-5.02 mg GALAE/g; root: 2.93-4.17 mg GALAE/g). Overall, this study presented an interesting scope of this species in phytomedicine with preliminary data demonstrating some of the tested extracts to possess high bioactive contents, antioxidant potential and enzyme inhibitory activity. Thus, additional investigations are necessary to confirm their safety in herbal drug applications.
Identifiants
pubmed: 35263028
doi: 10.1002/cbdv.202200076
doi:
Substances chimiques
Antioxidants
0
Flavonoids
0
Phytochemicals
0
Plant Extracts
0
Water
059QF0KO0R
Ethanol
3K9958V90M
Acetylcholinesterase
EC 3.1.1.7
Butyrylcholinesterase
EC 3.1.1.8
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e202200076Informations de copyright
© 2022 Wiley-VHCA AG, Zurich, Switzerland.
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