Pulmonary microbiome and gene expression signatures differentiate lung function in pediatric hematopoietic cell transplant candidates.
Journal
Science translational medicine
ISSN: 1946-6242
Titre abrégé: Sci Transl Med
Pays: United States
ID NLM: 101505086
Informations de publication
Date de publication:
09 03 2022
09 03 2022
Historique:
entrez:
9
3
2022
pubmed:
10
3
2022
medline:
27
4
2022
Statut:
ppublish
Résumé
Impaired baseline lung function is associated with mortality after pediatric allogeneic hematopoietic cell transplantation (HCT), yet limited knowledge of the molecular pathways that characterize pretransplant lung function has hindered the development of lung-targeted interventions. In this study, we quantified the association between bronchoalveolar lavage (BAL) metatranscriptomes and paired pulmonary function tests performed a median of 1 to 2 weeks before allogeneic HCT in 104 children in The Netherlands. Abnormal pulmonary function was recorded in more than half the cohort, consisted most commonly of restriction and impaired diffusion, and was associated with both all-cause and lung injury-related mortality after HCT. Depletion of commensal supraglottic taxa, such as
Identifiants
pubmed: 35263147
doi: 10.1126/scitranslmed.abm8646
pmc: PMC9487170
mid: NIHMS1834244
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
eabm8646Subventions
Organisme : NIAID NIH HHS
ID : T32 AI060537
Pays : United States
Organisme : NHLBI NIH HHS
ID : R35 HL140026
Pays : United States
Organisme : NHLBI NIH HHS
ID : K23 HL146936
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL134828
Pays : United States
Organisme : NIAID NIH HHS
ID : F31 AI150007
Pays : United States
Organisme : Howard Hughes Medical Institute
Pays : United States
Organisme : NICHD NIH HHS
ID : K12 HD000850
Pays : United States
Organisme : NHLBI NIH HHS
ID : L40 HL138866
Pays : United States
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