Overcoming drug resistance by targeting protein homeostasis in multiple myeloma.
Multiple myeloma
drug resistance
endoplasmic reticulum stress
immunomodulatory drugs
proteasome inhibitors
proteostasis
unfolded protein response
Journal
Cancer drug resistance (Alhambra, Calif.)
ISSN: 2578-532X
Titre abrégé: Cancer Drug Resist
Pays: United States
ID NLM: 101738710
Informations de publication
Date de publication:
2021
2021
Historique:
entrez:
10
3
2022
pubmed:
1
1
2021
medline:
1
1
2021
Statut:
ppublish
Résumé
Multiple myeloma (MM) is a plasma cell disorder typically characterized by abundant synthesis of clonal immunoglobulin or free light chains. Although incurable, a deeper understanding of MM pathobiology has fueled major therapeutical advances over the past two decades, significantly improving patient outcomes. Proteasome inhibitors, immunomodulatory drugs, and monoclonal antibodies are among the most effective anti-MM drugs, targeting not only the cancerous cells, but also the bone marrow microenvironment. However,
Identifiants
pubmed: 35265794
doi: 10.20517/cdr.2021.93
pmc: PMC8903187
mid: NIHMS1770730
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1028-1046Subventions
Organisme : NCI NIH HHS
ID : K08 CA245100
Pays : United States
Déclaration de conflit d'intérêts
Conflicts of interest All authors declared that there are no conflicts of interest.
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