Emerging natural recombinant Marek's disease virus between vaccine and virulence strains and their pathogenicity.
Marek's disease virus
genetic diversity
pathogenicity
recombination
vaccine
Journal
Transboundary and emerging diseases
ISSN: 1865-1682
Titre abrégé: Transbound Emerg Dis
Pays: Germany
ID NLM: 101319538
Informations de publication
Date de publication:
Sep 2022
Sep 2022
Historique:
revised:
17
02
2022
received:
07
12
2021
accepted:
05
03
2022
pubmed:
11
3
2022
medline:
30
9
2022
entrez:
10
3
2022
Statut:
ppublish
Résumé
Marek's disease virus (MDV), an oncogenic virus belonging to the subfamily Alphaherpesvirinae, causes Marek's disease (MD). Vaccines can control MD but cannot block the viral infection; they are considered imperfect vaccines, which carry the risk of recombination. In this study, six natural recombinant MDV strains were isolated from infected chickens in commercial flocks in China. We sequenced and analysed the genetic characteristics of the isolates (HC/0803, CH/10, SY/1219, DH/1307, DH/1504 and Hrb/1504). We found that the six strains resulted from recombination between the vaccine CVI988/Rispens (CVI988) strain skeleton and the virulence strain's partial unique short region. Additionally, a pathogenicity study was performed on recombinant strains (HC/0803 and DH/1307) and reference strains (CVI988 and LHC2) to evaluate their virulence. LHC2 induced 84.6% mortality in infected chickens; however, no mortality was recorded in chickens inoculated with HC/0803, DH/1307 or CVI988. However, HC/0803 and DH/1307 induced a notable spleen enlargement, and mild thymus and bursa atrophy at 11-17 days post-challenge (dpc). The viral genome load in the HC/0803- and DH/1307-challenged chickens peaked at approximately 10
Substances chimiques
Marek Disease Vaccines
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e1702-e1709Subventions
Organisme : National Natural Science Foundation of China
ID : 32170170
Organisme : National Natural Science Foundation of China
ID : U21A20260
Organisme : National Natural Science Foundation of China
ID : U20A2061
Organisme : China Agriculture Research System
ID : CARS-41-G15
Informations de copyright
© 2022 Wiley-VCH GmbH.
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