Antimicrobial Susceptibility Survey of Invasive Neisseria meningitidis, United States 2012-2016.
Neisseria meningitidis
penA
antibiotic resistance
antimicrobial susceptibility
ciprofloxacin
invasive meningococcal disease
penicillin
Journal
The Journal of infectious diseases
ISSN: 1537-6613
Titre abrégé: J Infect Dis
Pays: United States
ID NLM: 0413675
Informations de publication
Date de publication:
01 06 2022
01 06 2022
Historique:
received:
08
11
2021
accepted:
08
02
2022
pubmed:
11
3
2022
medline:
7
6
2022
entrez:
10
3
2022
Statut:
ppublish
Résumé
Historically, antimicrobial resistance has been rare in US invasive meningococcal disease cases. Meningococcal isolates (n = 695) were collected through population-based surveillance, 2012-2016, and national surveillance, 2015-2016. Antimicrobial susceptibility was assessed by broth microdilution. Resistance mechanisms were characterized using whole-genome sequencing. All isolates were susceptible to 6 antibiotics (cefotaxime, ceftriaxone, meropenem, rifampin, minocycline, and azithromycin). Approximately 25% were penicillin or ampicillin intermediate; among these, 79% contained mosaic penA gene mutations. Less than 1% of isolates were penicillin, ampicillin, ciprofloxacin, or levofloxacin resistant. Penicillin- and ampicillin-intermediate isolates were common, but resistance to clinically relevant antibiotics remained rare.
Sections du résumé
BACKGROUND
Historically, antimicrobial resistance has been rare in US invasive meningococcal disease cases.
METHODS
Meningococcal isolates (n = 695) were collected through population-based surveillance, 2012-2016, and national surveillance, 2015-2016. Antimicrobial susceptibility was assessed by broth microdilution. Resistance mechanisms were characterized using whole-genome sequencing.
RESULTS
All isolates were susceptible to 6 antibiotics (cefotaxime, ceftriaxone, meropenem, rifampin, minocycline, and azithromycin). Approximately 25% were penicillin or ampicillin intermediate; among these, 79% contained mosaic penA gene mutations. Less than 1% of isolates were penicillin, ampicillin, ciprofloxacin, or levofloxacin resistant.
CONCLUSIONS
Penicillin- and ampicillin-intermediate isolates were common, but resistance to clinically relevant antibiotics remained rare.
Identifiants
pubmed: 35266516
pii: 6546244
doi: 10.1093/infdis/jiac046
doi:
Substances chimiques
Anti-Bacterial Agents
0
Penicillins
0
Ciprofloxacin
5E8K9I0O4U
Ceftriaxone
75J73V1629
Ampicillin
7C782967RD
Types de publication
Journal Article
Research Support, U.S. Gov't, P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
1871-1875Subventions
Organisme : CDC HHS
Pays : United States
Commentaires et corrections
Type : CommentIn
Informations de copyright
Published by Oxford University Press for the Infectious Diseases Society of America 2022.