Do basophil activation tests help elucidate allergic reactions to the ingredients in COVID-19 vaccines?
COVID-19 vaccines
basophil activation test
basophil histamine release test
mRNA vaccines
polyethylene glycol (PEG)
Journal
Allergy
ISSN: 1398-9995
Titre abrégé: Allergy
Pays: Denmark
ID NLM: 7804028
Informations de publication
Date de publication:
10 2022
10 2022
Historique:
revised:
28
02
2022
received:
16
12
2021
accepted:
07
03
2022
pubmed:
11
3
2022
medline:
1
10
2022
entrez:
10
3
2022
Statut:
ppublish
Résumé
The worldwide use of COVID-19 vaccines has shown that immediate allergic reactions to the ingredients are rare but should be clarified by means of an allergological work-up. This review aims to highlight the current state of knowledge and possible pathogenesis based on the literature published to date. In addition to recording a detailed history and performing skin tests, cellular tests (basophil activation or basophil histamine release test) by using the vaccines or modified compounds containing polyethylene glycol (PEG), rather than unmodified PEGs, have proven to be particularly helpful. Negative results with vaccines seem to indicate tolerance. Details of the performance of these cellular tests with different vaccines, PEGs of different molecular weights, other ingredients of the vaccines, as well as other PEGylated drugs, and the results in the context of COVID-19 vaccination of various working groups worldwide are summarized.
Identifiants
pubmed: 35266570
doi: 10.1111/all.15278
pmc: PMC9111482
doi:
Substances chimiques
COVID-19 Vaccines
0
Polyethylene Glycols
3WJQ0SDW1A
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
2924-2936Informations de copyright
© 2022 The Authors. Allergy published by European Academy of Allergy and Clinical Immunology and John Wiley & Sons Ltd.
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