Gestational Perfluoroalkyl Substance Exposure and DNA Methylation at Birth and 12 Years of Age: A Longitudinal Epigenome-Wide Association Study.

Adolescent Alkanesulfonic Acids Child DNA Methylation Environmental Pollutants Epigenome Female Fluorocarbons Humans Infant, Newborn Longitudinal Studies Pregnancy

Journal

Environmental health perspectives
ISSN: 1552-9924
Titre abrégé: Environ Health Perspect
Pays: United States
ID NLM: 0330411

Informations de publication

Date de publication:
03 2022
Historique:
entrez: 10 3 2022
pubmed: 11 3 2022
medline: 18 3 2022
Statut: ppublish

Résumé

DNA methylation alterations may underlie associations between gestational perfluoroalkyl substances (PFAS) exposure and later-life health outcomes. To the best of our knowledge, no longitudinal studies have examined the associations between gestational PFAS and DNA methylation. We examined associations of gestational PFAS exposure with longitudinal DNA methylation measures at birth and in adolescence using the Health Outcomes and Measures of the Environment (HOME) Study (2003-2006; Cincinnati, Ohio). We quantified serum concentrations of perfluorooctanoate (PFOA), perfluorooctane sulfonate (PFOS), perfluorononanoate (PFNA), and perfluorohexane sulfonate (PFHxS) in mothers during pregnancy. We measured DNA methylation in cord blood ( After adjusting for covariates, 435 cytosine-guanine dinucleotide (CpG) sites were associated with PFAS (false discovery rate, In these longitudinal data, PFAS biomarkers were associated with differences in several CpGs at birth and at 12 years of age in or near genes linked to some PFAS-associated health outcomes. Future studies should examine whether DNA methylation mediates associations between gestational PFAS exposure and health. https://doi.org/10.1289/EHP10118.

Sections du résumé

BACKGROUND
DNA methylation alterations may underlie associations between gestational perfluoroalkyl substances (PFAS) exposure and later-life health outcomes. To the best of our knowledge, no longitudinal studies have examined the associations between gestational PFAS and DNA methylation.
OBJECTIVES
We examined associations of gestational PFAS exposure with longitudinal DNA methylation measures at birth and in adolescence using the Health Outcomes and Measures of the Environment (HOME) Study (2003-2006; Cincinnati, Ohio).
METHODS
We quantified serum concentrations of perfluorooctanoate (PFOA), perfluorooctane sulfonate (PFOS), perfluorononanoate (PFNA), and perfluorohexane sulfonate (PFHxS) in mothers during pregnancy. We measured DNA methylation in cord blood (
RESULTS
After adjusting for covariates, 435 cytosine-guanine dinucleotide (CpG) sites were associated with PFAS (false discovery rate,
DISCUSSION
In these longitudinal data, PFAS biomarkers were associated with differences in several CpGs at birth and at 12 years of age in or near genes linked to some PFAS-associated health outcomes. Future studies should examine whether DNA methylation mediates associations between gestational PFAS exposure and health. https://doi.org/10.1289/EHP10118.

Identifiants

DOI: 10.1289/EHP10118 PMID: 35266797 PMC: PMC8911098
pubmed: 35266797
doi: 10.1289/EHP10118
pmc: PMC8911098
doi:

Substances chimiques

Alkanesulfonic Acids 0
Environmental Pollutants 0
Fluorocarbons 0

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

37005

Subventions

Organisme : NIEHS NIH HHS
ID : R01 ES030078
Pays : United States
Organisme : NIEHS NIH HHS
ID : R01 ES027224
Pays : United States
Organisme : NIH HHS
ID : UH3 OD023286
Pays : United States
Organisme : NIEHS NIH HHS
ID : L40 ES032257
Pays : United States
Organisme : NIEHS NIH HHS
ID : P01 ES011261
Pays : United States
Organisme : NIEHS NIH HHS
ID : R01 ES032836
Pays : United States
Organisme : NIEHS NIH HHS
ID : P30 ES006096
Pays : United States
Organisme : NIH HHS
ID : UG3 OD023286
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD034568
Pays : United States
Organisme : NIEHS NIH HHS
ID : R01 ES025214
Pays : United States
Organisme : NIEHS NIH HHS
ID : R01 ES020349
Pays : United States

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Auteurs

Yun Liu (Y)

Department of Epidemiology, Brown University School of Public Health, Providence, Rhode Island, USA.
ORCID: 0000-0002-2979-9552

Melissa N Eliot (MN)

Department of Epidemiology, Brown University School of Public Health, Providence, Rhode Island, USA.

George D Papandonatos (GD)

Department of Biostatistics, Brown University School of Public Health, Providence, Rhode Island, USA.

Karl T Kelsey (KT)

Department of Epidemiology, Brown University School of Public Health, Providence, Rhode Island, USA.
Department of Laboratory Medicine and Pathology, Brown University, Providence, Rhode Island, USA.
ORCID: 0000-0002-2302-1600

Ruby Fore (R)

Department of Population Medicine, Harvard Pilgrim Health Care Institute, Harvard Medical School, Boston, Massachusetts, USA.

Scott Langevin (S)

Department of Environmental & Public Health Sciences, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
ORCID: 0000-0001-7031-1216

Jessie Buckley (J)

Department of Environmental Health and Engineering, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA.
ORCID: 0000-0001-7976-0157

Aimin Chen (A)

Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.

Bruce P Lanphear (BP)

Faculty of Health Sciences, Simon Fraser University, Burnaby, British Columbia, Canada.

Kim M Cecil (KM)

Department of Environmental & Public Health Sciences, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
Department of Radiology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
ORCID: 0000-0001-8233-5485

Kimberly Yolton (K)

Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
ORCID: 0000-0002-4458-0516

Marie-France Hivert (MF)

Department of Population Medicine, Harvard Pilgrim Health Care Institute, Harvard Medical School, Boston, Massachusetts, USA.
Diabetes Unit, Massachusetts General Hospital, Boston, Massachusetts, USA.
ORCID: 0000-0001-7752-2585

Sharon K Sagiv (SK)

Department of Epidemiology, Berkeley School of Public Health, University of California, Berkeley, California, USA.

Andrea A Baccarelli (AA)

Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, New York, USA.

Emily Oken (E)

Department of Population Medicine, Harvard Pilgrim Health Care Institute, Harvard Medical School, Boston, Massachusetts, USA.

Joseph M Braun (JM)

Department of Epidemiology, Brown University School of Public Health, Providence, Rhode Island, USA.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adolescent › Gestational Perfluoroalkyl Substance Exposure...
questionsmedicales.fr › Composés chimiques organiques › Composés du soufre › Acides du soufre › Acides sulfoniques › Acides alcanesulfoniques › Gestational Perfluoroalkyl Substance Exposure...
questionsmedicales.fr › Personnes › Tranches d'âge › Enfant › Gestational Perfluoroalkyl Substance Exposure...
questionsmedicales.fr › Phénomènes génétiques › Méthylation de l'ADN › Gestational Perfluoroalkyl Substance Exposure...
questionsmedicales.fr › Actions chimiques et utilisations › Actions toxiques › Polluants environnementaux › Gestational Perfluoroalkyl Substance Exposure...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Épigénome › Gestational Perfluoroalkyl Substance Exposure...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures halogénés › Hydrocarbures fluorés › Fluorocarbones › Gestational Perfluoroalkyl Substance Exposure...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Gestational Perfluoroalkyl Substance Exposure...
questionsmedicales.fr › Personnes › Tranches d'âge › Nourrisson › Nouveau-né › Gestational Perfluoroalkyl Substance Exposure...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études longitudinales › Gestational Perfluoroalkyl Substance Exposure...
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Reproduction › Grossesse › Gestational Perfluoroalkyl Substance Exposure...