Structural and Biochemical Basis for Development of Diketo Acid Inhibitors Targeting the Cap-Snatching Endonuclease of the Ebinur Lake Virus (Order:
Antiviral Agents
/ chemical synthesis
Bunyaviridae
/ enzymology
Bunyaviridae Infections
/ drug therapy
Endonucleases
/ metabolism
Enzyme Activation
/ drug effects
Enzyme Inhibitors
/ chemical synthesis
Humans
Hydroxybutyrates
/ chemistry
Piperidines
/ chemistry
Structure-Activity Relationship
Viral Proteins
/ metabolism
Ebinur Lake virus
bunyavirus
cap-snatching endonuclease
diketo acid inhibitor
structure-activity relationship
Journal
Journal of virology
ISSN: 1098-5514
Titre abrégé: J Virol
Pays: United States
ID NLM: 0113724
Informations de publication
Date de publication:
13 04 2022
13 04 2022
Historique:
pubmed:
11
3
2022
medline:
16
4
2022
entrez:
10
3
2022
Statut:
ppublish
Résumé
The
Identifiants
pubmed: 35266805
doi: 10.1128/jvi.02173-21
pmc: PMC9006905
doi:
Substances chimiques
Antiviral Agents
0
Enzyme Inhibitors
0
Hydroxybutyrates
0
L-742,001
0
Piperidines
0
Viral Proteins
0
Endonucleases
EC 3.1.-
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0217321Références
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