Angiogenesis: A Pivotal Therapeutic Target in the Drug Development of Gynecologic Cancers.
angiogenesis
targeted therapy
tumor microenvironment
vascular endothelial growth factor
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
22 Feb 2022
22 Feb 2022
Historique:
received:
07
01
2022
revised:
16
02
2022
accepted:
17
02
2022
entrez:
10
3
2022
pubmed:
11
3
2022
medline:
11
3
2022
Statut:
epublish
Résumé
Since the discovery of angiogenesis and its relevance to the tumorigenesis of gynecologic malignancies, a number of therapeutic agents have been developed over the last decade, some of which have become standard treatments in combination with other therapies. Limited clinical activity has been demonstrated with anti-angiogenic monotherapies, and ongoing trials are focused on combination strategies with cytotoxic agents, immunotherapies and other targeted treatments. This article reviews the science behind angiogenesis within the context of gynecologic cancers, the evidence supporting the targeting of these pathways and future directions in clinical trials.
Identifiants
pubmed: 35267430
pii: cancers14051122
doi: 10.3390/cancers14051122
pmc: PMC8908988
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
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