CK1 Is a Druggable Regulator of Microtubule Dynamics and Microtubule-Associated Processes.
CK1
Casein Kinase 1
MAPs
RITA1
cell cycle progression
microtubule dynamics
microtubule transport
microtubule-associated proteins
mitotic spindle
tumorigenesis
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
05 Mar 2022
05 Mar 2022
Historique:
received:
02
02
2022
revised:
25
02
2022
accepted:
03
03
2022
entrez:
10
3
2022
pubmed:
11
3
2022
medline:
11
3
2022
Statut:
epublish
Résumé
Protein kinases of the Casein Kinase 1 family play a vital role in the regulation of numerous cellular processes. Apart from functions associated with regulation of proliferation, differentiation, or apoptosis, localization of several Casein Kinase 1 isoforms to the centrosome and microtubule asters also implicates regulatory functions in microtubule dynamic processes. Being localized to the spindle apparatus during mitosis Casein Kinase 1 directly modulates microtubule dynamics by phosphorylation of tubulin isoforms. Additionally, site-specific phosphorylation of microtubule-associated proteins can be related to the maintenance of genomic stability but also microtubule stabilization/destabilization, e.g., by hyper-phosphorylation of microtubule-associated protein 1A and RITA1. Consequently, approaches interfering with Casein Kinase 1-mediated microtubule-specific functions might be exploited as therapeutic strategies for the treatment of cancer. Currently pursued strategies include the development of Casein Kinase 1 isoform-specific small molecule inhibitors and therapeutically useful peptides specifically inhibiting kinase-substrate interactions.
Identifiants
pubmed: 35267653
pii: cancers14051345
doi: 10.3390/cancers14051345
pmc: PMC8909099
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : Deutsche Forschungsgemeinschaft
ID : GSC 270
Organisme : Deutsche Forschungsgemeinschaft
ID : GRK2254/C4
Organisme : Deutsche Forschungsgemeinschaft
ID : SFB1074/A3
Organisme : Deutsche Forschungsgemeinschaft
ID : SFB1506/A5
Organisme : Deutsche Forschungsgemeinschaft
ID : OS 287/4-1
Organisme : Deutsche Forschungsgemeinschaft
ID : KN356/9-1
Organisme : German Cancer Aid
ID : #70114289
Organisme : Else Kröner-Fresenius-Stiftung
ID : 2017_A142
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