Vitamin K Supplementation for Prevention of Vascular Calcification in Chronic Kidney Disease Patients: Are We There Yet?
Matrix Gla Protein
cardiovascular disease
chronic kidney disease
end-stage kidney disease
hemodialysis
menaquinone-7
vascular calcification
vitamin K
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
22 Feb 2022
22 Feb 2022
Historique:
received:
30
12
2021
revised:
07
02
2022
accepted:
19
02
2022
entrez:
10
3
2022
pubmed:
11
3
2022
medline:
15
3
2022
Statut:
epublish
Résumé
Chronic Kidney Disease (CKD) patients are at high risk of presenting with arterial calcification or stiffness, which confers increased cardiovascular mortality and morbidity. In recent years, it has become evident that VC is an active process regulated by various molecules that may act as inhibitors of vessel mineralization. Matrix Gla Protein (MGP), one the most powerful naturally occurring inhibitors of arterial calcification, requires vitamin K as a co-factor in order to undergo post-translational γ-carboxylation and phosphrorylation and become biologically active. The inactive form of MGP (dephosphorylated, uncarboxylated dp-ucMGP) reflects vitamin K deficiency and has been repeatedly associated with surrogate markers of VC, stiffness, and cardiovascular outcomes in CKD populations. As CKD is a state of progressive vitamin K depletion and VC, research has focused on clinical trials aiming to investigate the possible beneficial effects of vitamin K in CKD and dialysis patients. In this study, we aim to review the current evidence regarding vitamin K supplementation in uremic patients.
Identifiants
pubmed: 35267901
pii: nu14050925
doi: 10.3390/nu14050925
pmc: PMC8912443
pii:
doi:
Substances chimiques
Vitamin K
12001-79-5
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Références
Protein Sci. 2001 Apr;10(4):864-70
pubmed: 11274477
J Am Soc Nephrol. 2004 Nov;15(11):2857-67
pubmed: 15504939
J Am Heart Assoc. 2021 Aug 17;10(16):e020551
pubmed: 34369182
Blood Purif. 2007;25(5-6):395-401
pubmed: 17890861
Obstet Gynecol. 1990 Mar;75(3 Pt 1):334-7
pubmed: 2304704
Am J Kidney Dis. 1998 Nov;32(5):853-906
pubmed: 9820460
Osteoporos Int. 2015 Mar;26(3):1053-61
pubmed: 25403902
Nephrol Dial Transplant. 2004 Sep;19(9):2387-93
pubmed: 15252163
Nutrients. 2017 Dec 08;9(12):
pubmed: 29292751
Am J Kidney Dis. 2003 Aug;42(2):303-9
pubmed: 12900812
Medicine (Baltimore). 2020 Sep 4;99(36):e21906
pubmed: 32899022
Nephrol Dial Transplant. 2014 Jul;29(7):1385-90
pubmed: 24285428
J Am Soc Nephrol. 2020 Oct;31(10):2434-2445
pubmed: 32817311
J Cell Biochem. 2003 Nov 1;90(4):756-65
pubmed: 14587031
J Am Coll Cardiol. 2004 May 5;43(9):1663-9
pubmed: 15120828
J Biol Chem. 2001 Apr 27;276(17):14044-52
pubmed: 11278388
Am J Clin Nutr. 2010 May;91(5):1348-58
pubmed: 20335553
Semin Nephrol. 2014 Nov;34(6):648-59
pubmed: 25498383
Cell Physiol Biochem. 2014;34(6):2049-60
pubmed: 25562153
Eur J Nutr. 2021 Apr;60(3):1701-1702
pubmed: 33532875
Arterioscler Thromb Vasc Biol. 2005 Aug;25(8):1629-33
pubmed: 15961706
Blood. 2007 Apr 1;109(7):2823-31
pubmed: 17138823
Hypertension. 2017 Jun;69(6):1165-1172
pubmed: 28396533
Nutrients. 2020 Sep 23;12(10):
pubmed: 32977548
J Cell Physiol. 2000 Jul;184(1):37-45
pubmed: 10825232
Nephrol Dial Transplant. 2014 Sep;29(9):1633-8
pubmed: 24285427
Can J Kidney Health Dis. 2015 May 01;2:17
pubmed: 26075081
Diab Vasc Dis Res. 2018 Mar;15(2):99-105
pubmed: 29168393
Am J Hypertens. 2018 May 7;31(6):735-741
pubmed: 29635270
Semin Dial. 2007 Mar-Apr;20(2):113-21
pubmed: 17374084
Ren Fail. 2019 Nov;41(1):131-138
pubmed: 30909780
J Thromb Haemost. 2007 Dec;5(12):2503-11
pubmed: 17848178
Eur J Nutr. 2019 Sep;58(6):2191-2205
pubmed: 31119401
J Nutr. 2020 Dec 10;150(12):3171-3179
pubmed: 33119768
Nature. 1997 Mar 6;386(6620):78-81
pubmed: 9052783
PLoS One. 2015 Nov 10;10(11):e0142335
pubmed: 26555788
J Am Soc Hypertens. 2017 Sep;11(9):589-597
pubmed: 28756183
Kidney Int. 2022 Feb;101(2):338-348
pubmed: 34774554
J Diabetes Complications. 2017 Oct;31(10):1527-1532
pubmed: 28734846
J Am Soc Nephrol. 2011 Feb;22(2):387-95
pubmed: 21289218
Am J Nephrol. 2005 Nov-Dec;25(6):548-52
pubmed: 16210837
J Am Soc Nephrol. 2005 Feb;16(2):489-95
pubmed: 15590763
Kidney Int. 2005 Jun;67(6):2295-304
pubmed: 15882271
Int J Endocrinol. 2017;2017:7454376
pubmed: 29138634
Kidney Dis (Basel). 2017 Jul;3(1):15-23
pubmed: 28785560
J Biol Chem. 2002 Feb 8;277(6):4388-94
pubmed: 11741887
J Nutr. 2004 Nov;134(11):3100-5
pubmed: 15514282
Clin Nutr. 2015 Apr;34(2):235-40
pubmed: 24745600
Am J Hypertens. 2018 Aug 3;31(9):988-994
pubmed: 29788226
J Am Soc Nephrol. 2006 Jan;17(1):262-70
pubmed: 16280472
Nutrients. 2021 Oct 12;13(10):
pubmed: 34684568
Nephrol Dial Transplant. 2016 Jan;31(1):31-9
pubmed: 25916871
Kidney Int. 2008 May;73(9):1024-30
pubmed: 18288101
Pol Arch Med Wewn. 2015;125(9):631-40
pubmed: 26176325
Thromb Haemost. 2000 Dec;84(6):1039-44
pubmed: 11154111
Nephrol Dial Transplant. 2007 Nov;22(11):3208-13
pubmed: 17617653
J Am Soc Nephrol. 2017 Jun;28(6):1717-1722
pubmed: 28049648
Pediatr Nephrol. 2016 Feb;31(2):195-206
pubmed: 25735207
Toxicol Mech Methods. 2011 Sep;21(7):520-32
pubmed: 21781006
Kidney Int. 2014 Aug;86(2):286-93
pubmed: 24429407
Oxid Med Cell Longev. 2017 Dec 27;2017:3494867
pubmed: 29750088
J Thromb Haemost. 2003 Jan;1(1):178-85
pubmed: 12871556
Int Urol Nephrol. 2019 Nov;51(11):2037-2044
pubmed: 31529295
Nephron. 2017;135(3):167-172
pubmed: 27951533
Nephrol Dial Transplant. 2015 Aug;30(8):1345-56
pubmed: 25854266
Br J Haematol. 2016 Sep;174(6):989-90
pubmed: 26492096
Clin Nephrol. 2009 Aug;72(2):114-21
pubmed: 19640368
Vasc Health Risk Manag. 2009;5(1):185-97
pubmed: 19436645
J Clin Med. 2020 Jul 23;9(8):
pubmed: 32718053
BMC Nephrol. 2014 Sep 04;15:145
pubmed: 25190488
PLoS One. 2012;7(5):e36175
pubmed: 22567137
BMC Nephrol. 2017 Jun 7;18(1):191
pubmed: 28592319
Am J Kidney Dis. 2012 Feb;59(2):186-95
pubmed: 22169620
Nat Genet. 1999 Jan;21(1):142-4
pubmed: 9916809
Kidney Int. 2010 Dec;78(12):1232-9
pubmed: 20861819
Clin Kidney J. 2021 Jan 28;14(9):2114-2123
pubmed: 34476095
Int J Mol Sci. 2020 Aug 21;21(17):
pubmed: 32839405
Heart. 2019 Jun;105(12):938-945
pubmed: 30514729
Kidney Int. 2012 Sep;82(5):605-10
pubmed: 22648294
Kidney Int. 2017 Dec;92(6):1384-1394
pubmed: 28844316
J Am Soc Nephrol. 2011 Jan;22(1):124-36
pubmed: 21115613
Nephrol Dial Transplant. 2006 May;21(5):1407-12
pubmed: 16504981
Front Med (Lausanne). 2020 Apr 24;7:154
pubmed: 32391368
Curr Vasc Pharmacol. 2021;19(1):77-90
pubmed: 32196451
Lancet. 1995 Jan 28;345(8944):229-34
pubmed: 7823718
Int J Mol Sci. 2019 Feb 01;20(3):
pubmed: 30717170
J Cell Biol. 2004 Jun 7;165(5):625-30
pubmed: 15184399
J Am Soc Nephrol. 2008 Jun;19(6):1092-105
pubmed: 18417722
Am J Transplant. 2021 Oct;21(10):3356-3368
pubmed: 33742520
Am J Pathol. 2011 Jun;178(6):2879-87
pubmed: 21531376
Eur J Clin Nutr. 2021 Nov 29;:
pubmed: 34845313
Curr Opin Nephrol Hypertens. 2004 Jul;13(4):417-22
pubmed: 15199292
Am J Kidney Dis. 2004 Feb;43(2):234-43
pubmed: 14750088
J Hypertens. 2010 Jan;28(1):163-9
pubmed: 19927012
Oxid Med Cell Longev. 2017;2017:3081856
pubmed: 29138677
Adv Clin Chem. 2020;98:91-147
pubmed: 32564789
Clin J Am Soc Nephrol. 2010 Apr;5(4):568-75
pubmed: 20133489
Am J Kidney Dis. 2015 Mar;65(3):474-83
pubmed: 25453995
J Am Soc Nephrol. 2020 Jan;31(1):186-196
pubmed: 31704740
Am J Kidney Dis. 2007 Mar;49(3):432-9
pubmed: 17336705
BMC Nephrol. 2017 May 2;18(1):149
pubmed: 28464802
J Am Coll Cardiol. 2002 Feb 20;39(4):695-701
pubmed: 11849871