Cardioprotective Properties of Humoral Factors Released after Remote Ischemic Preconditioning in CABG Patients with Propofol-Free Anesthesia-A Translational Approach from Bedside to Bench.
cardioprotection
diabetes mellitus
remote ischemic preconditioning
reperfusion injury
Journal
Journal of clinical medicine
ISSN: 2077-0383
Titre abrégé: J Clin Med
Pays: Switzerland
ID NLM: 101606588
Informations de publication
Date de publication:
07 Mar 2022
07 Mar 2022
Historique:
received:
07
02
2022
revised:
27
02
2022
accepted:
04
03
2022
entrez:
10
3
2022
pubmed:
11
3
2022
medline:
11
3
2022
Statut:
epublish
Résumé
The cardioprotective effect of remote ischemic preconditioning (RIPC) is well detectable in experimental studies but not in clinical trials. Propofol, a commonly used sedative, is discussed to negatively influence the release of humoral factors after RIPC. Further, results from experimental and clinical trials suggest various comorbidities interact with inducible cardioprotective properties of RIPC. In the present study, we went back from bedside to bench to investigate, in male patients undergoing CABG surgery, whether (1) humoral factors are released after RIPC during propofol-free anesthesia and/or (2) DM interacts with plasma factor release. Blood samples were taken from male patients with and without DM undergoing CABG surgery before (control) and after RIPC (RIPC). To investigate the release of cardioprotective humoral factors into the plasma, isolated perfused hearts of young rats (
Identifiants
pubmed: 35268540
pii: jcm11051450
doi: 10.3390/jcm11051450
pmc: PMC8910912
pii:
doi:
Types de publication
Journal Article
Langues
eng
Références
Acta Anaesthesiol Scand. 2014 Apr;58(4):453-62
pubmed: 24548338
Anesth Analg. 2020 Dec;131(6):1765-1780
pubmed: 33186163
Lancet. 2013 Aug 17;382(9892):597-604
pubmed: 23953384
J Am Heart Assoc. 2018 Mar 26;7(7):
pubmed: 29581218
N Engl J Med. 2015 Oct 8;373(15):1408-17
pubmed: 26436207
Circulation. 2009 Feb 17;119(6):820-7
pubmed: 19188504
Crit Care Med. 2019 Mar;47(3):e250-e255
pubmed: 30608281
Int J Mol Sci. 2021 Mar 03;22(5):
pubmed: 33802308
J Am Coll Cardiol. 2015 Jan 20;65(2):177-95
pubmed: 25593060
N Engl J Med. 2007 Sep 13;357(11):1121-35
pubmed: 17855673
Circ Res. 2016 Apr 1;118(7):1052-4
pubmed: 27034272
J Transl Med. 2018 Apr 27;16(1):112
pubmed: 29703217
J Cardiothorac Vasc Anesth. 2017 Aug;31(4):1223-1226
pubmed: 27793521
Int J Mol Sci. 2021 Nov 19;22(22):
pubmed: 34830353
Br J Anaesth. 2008 Apr;100(4):465-71
pubmed: 18305078
Front Physiol. 2012 Feb 20;3:27
pubmed: 22363297
J Am Coll Cardiol. 2010 Jul 20;56(4):254-63
pubmed: 20633817
Cardiovasc Diabetol. 2019 May 31;18(1):66
pubmed: 31151453
Acta Physiol (Oxf). 2007 Jun;190(2):103-9
pubmed: 17394577
Br J Pharmacol. 2020 Dec;177(23):5252-5269
pubmed: 31430831
Nat Rev Cardiol. 2020 Dec;17(12):773-789
pubmed: 32620851
World J Diabetes. 2015 Oct 10;6(13):1246-58
pubmed: 26468341
Int J Mol Sci. 2021 Aug 18;22(16):
pubmed: 34445586
Int J Mol Sci. 2019 Sep 29;20(19):
pubmed: 31569468
Oncotarget. 2019 Jan 4;10(2):216-244
pubmed: 30719216
Circ Res. 2017 Apr 28;120(9):1477-1486
pubmed: 28450365
Am J Physiol Heart Circ Physiol. 2001 Apr;280(4):H1744-50
pubmed: 11247788
Acta Anaesthesiol Scand. 2012 Jan;56(1):30-8
pubmed: 22103808