The Neurotoxicity of Vesicles Secreted by ALS Patient Myotubes Is Specific to Exosome-Like and Not Larger Subtypes.


Journal

Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052

Informations de publication

Date de publication:
01 03 2022
Historique:
received: 24 12 2021
revised: 21 02 2022
accepted: 25 02 2022
entrez: 10 3 2022
pubmed: 11 3 2022
medline: 12 4 2022
Statut: epublish

Résumé

Extracellular vesicles can mediate communication between tissues, affecting the physiological conditions of recipient cells. They are increasingly investigated in Amyotrophic Lateral Sclerosis, the most common form of Motor Neurone Disease, as transporters of misfolded proteins including SOD1, FUS, TDP43, or other neurotoxic elements, such as the dipeptide repeats resulting from

Identifiants

pubmed: 35269468
pii: cells11050845
doi: 10.3390/cells11050845
pmc: PMC8909615
pii:
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

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Auteurs

Ekene Anakor (E)

Personalised Medicine Centre, Biomedical Sciences Research Institute, Ulster University, Derry-Londonderry BT47 6SB, UK.

Vanessa Milla (V)

Personalised Medicine Centre, Biomedical Sciences Research Institute, Ulster University, Derry-Londonderry BT47 6SB, UK.

Owen Connolly (O)

Personalised Medicine Centre, Biomedical Sciences Research Institute, Ulster University, Derry-Londonderry BT47 6SB, UK.

Cecile Martinat (C)

I-STEM, INSERM/UEVE UMR 861, AFM, 91100 Corbeil-Essones, France.

Pierre Francois Pradat (PF)

Personalised Medicine Centre, Biomedical Sciences Research Institute, Ulster University, Derry-Londonderry BT47 6SB, UK.
Laboratoire d'Imagerie Biomédicale, Sorbonne Université, CNRS, INSERM, 75013 Paris, France.
Centre référent SLA, Département de Neurologie, Hôpital Pitié-Salpêtrière, APHP, 75013 Paris, France.

Julie Dumonceaux (J)

Personalised Medicine Centre, Biomedical Sciences Research Institute, Ulster University, Derry-Londonderry BT47 6SB, UK.
NIHR Biomedical Research Centre, Great Ormond Street Institute of Child Health, Great Ormond Street Hospital NHS Trust, University College London, London WC1N 1EH, UK.

William Duddy (W)

Personalised Medicine Centre, Biomedical Sciences Research Institute, Ulster University, Derry-Londonderry BT47 6SB, UK.

Stephanie Duguez (S)

Personalised Medicine Centre, Biomedical Sciences Research Institute, Ulster University, Derry-Londonderry BT47 6SB, UK.

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