The Effects of Prenatal Exposure to Pregabalin on the Development of Ventral Midbrain Dopaminergic Neurons.
embryonic neurons
neuropathic pain
pregabalin
ventral midbrain dopaminergic neurons
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
01 03 2022
01 03 2022
Historique:
received:
25
01
2022
revised:
21
02
2022
accepted:
26
02
2022
entrez:
10
3
2022
pubmed:
11
3
2022
medline:
12
4
2022
Statut:
epublish
Résumé
Pregabalin is widely used as a treatment for multiple neurological disorders; however, it has been reported to have the potential for misuse. Due to a lack of safety studies in pregnancy, pregabalin is considered the last treatment option for various neurological diseases, such as neuropathic pain. Therefore, pregabalin abuse in pregnant women, even at therapeutic doses, may impair fetal development. We used primary mouse embryonic neurons to investigate whether exposure to pregabalin can impair the morphogenesis and differentiation of ventral midbrain neurons. This study focused on ventral midbrain dopaminergic neurons, as they are responsible for cognition, movement, and behavior. The results showed that pregabalin exposure during early brain development induced upregulation of the dopaminergic progenitor genes
Identifiants
pubmed: 35269474
pii: cells11050852
doi: 10.3390/cells11050852
pmc: PMC8909856
pii:
doi:
Substances chimiques
Pregabalin
55JG375S6M
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Deputyship for Research & Innovation, Ministry of Education in Saudi Arabia
ID : 1-441-133
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