Artificial Tears: Biological Role of Their Ingredients in the Management of Dry Eye Disease.
artificial tears
cornea
dry eye disease
excipients
ingredients
ocular surface
tear film
tear substitutes
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
23 Feb 2022
23 Feb 2022
Historique:
received:
23
11
2021
revised:
17
12
2021
accepted:
18
12
2021
entrez:
10
3
2022
pubmed:
11
3
2022
medline:
30
3
2022
Statut:
epublish
Résumé
Dry eye disease (DED) is the most common ocular surface disease, characterized by insufficient production and/or instability of the tear film. Tear substitutes are usually the first line of treatment for patients with DED. Despite the large variety of tear substitutes available on the market, few studies have been performed to compare their performance. There is a need to better understand the specific mechanical and pharmacological roles of each ingredient composing the different formulations. In this review, we describe the main categories of ingredients composing tear substitutes (e.g., viscosity-enhancing agents, electrolytes, osmo-protectants, antioxidants, lipids, surfactants and preservatives) as well as their effects on the ocular surface, and we provide insight into how certain components of tear substitutes may promote corneal wound healing, and/or counteract inflammation. Based on these considerations, we propose an approach to select the most appropriate tear substitute formulations according to the predominant etiological causes of DED.
Identifiants
pubmed: 35269576
pii: ijms23052434
doi: 10.3390/ijms23052434
pmc: PMC8910031
pii:
doi:
Substances chimiques
Lubricant Eye Drops
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
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