The Interplay between Autonomic Nervous System and Inflammation across Systemic Autoimmune Diseases.
adaptive immunity
autonomic nervous system
gut microbiota
inflammation
inflammatory reflex
innate immunity
parasympathetic system
sympathetic system
systemic autoimmune diseases
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
23 Feb 2022
23 Feb 2022
Historique:
received:
02
02
2022
revised:
17
02
2022
accepted:
18
02
2022
entrez:
10
3
2022
pubmed:
11
3
2022
medline:
9
4
2022
Statut:
epublish
Résumé
The autonomic nervous system (ANS) and the immune system are deeply interrelated. The ANS regulates both innate and adaptive immunity through the sympathetic and parasympathetic branches, and an imbalance in this system can determine an altered inflammatory response as typically observed in chronic conditions such as systemic autoimmune diseases. Rheumatoid arthritis, systemic lupus erythematosus, and systemic sclerosis all show a dysfunction of the ANS that is mutually related to the increase in inflammation and cardiovascular risk. Moreover, an interaction between ANS and the gut microbiota has direct effects on inflammation homeostasis. Recently vagal stimulation techniques have emerged as an unprecedented possibility to reduce ANS dysfunction, especially in chronic diseases characterized by pain and a decreased quality of life as well as in chronic inflammation.
Identifiants
pubmed: 35269591
pii: ijms23052449
doi: 10.3390/ijms23052449
pmc: PMC8910153
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Italian Ministry of Health
ID : RC-2021-305.01
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