Friends with Benefits: Chemokines, Glioblastoma-Associated Microglia/Macrophages, and Tumor Microenvironment.
chemokine
dendritic cells
gene editing
glioblastoma
glioblastoma-associated macrophages
glioblastoma-associated microglia
myeloid-derived suppressor cells
soluble factors
specific receptors
tumor infiltrating lymphocytes
tumor microenvironment
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
24 Feb 2022
24 Feb 2022
Historique:
received:
27
01
2022
revised:
17
02
2022
accepted:
22
02
2022
entrez:
10
3
2022
pubmed:
11
3
2022
medline:
9
4
2022
Statut:
epublish
Résumé
Glioma is the most common primary intracranial tumor and has the greatest prevalence of all brain tumors. Treatment resistance and tumor recurrence in GBM are mostly explained by considerable alterations within the tumor microenvironment, as well as extraordinary cellular and molecular heterogeneity. Soluble factors, extracellular matrix components, tissue-resident cell types, resident or newly recruited immune cells together make up the GBM microenvironment. Regardless of many immune cells, a profound state of tumor immunosuppression is supported and developed, posing a considerable hurdle to cancer cells' immune-mediated destruction. Several studies have suggested that various GBM subtypes present different modifications in their microenvironment, although the importance of the microenvironment in treatment response has yet to be determined. Understanding the microenvironment and how it changes after therapies is critical because it can influence the remaining invasive GSCs and lead to recurrence. This review article sheds light on the various components of the GBM microenvironment and their roles in tumoral development, as well as immune-related biological processes that support the interconnection/interrelationship between different cell types. Also, we summarize the current understanding of the modulation of soluble factors and highlight the dysregulated inflammatory chemokine/specific receptors cascades/networks and their significance in tumorigenesis, cancer-related inflammation, and metastasis.
Identifiants
pubmed: 35269652
pii: ijms23052509
doi: 10.3390/ijms23052509
pmc: PMC8910233
pii:
doi:
Substances chimiques
Chemokines
0
Receptors, Chemokine
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Ministerul Cercetării și Inovării
ID : PNIII.P2-2.1-PED-2019-3141, PN 19.29.01.04, ID: P_40_197/2016, 31PFE/30.12.2021
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