Exudative versus Nonexudative Age-Related Macular Degeneration: Physiopathology and Treatment Options.
age-related macular degeneration
antiangiogenic agents
choroidal neovascularization
geographic atrophy
inflammatory cascade
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
26 Feb 2022
26 Feb 2022
Historique:
received:
10
02
2022
revised:
24
02
2022
accepted:
25
02
2022
entrez:
10
3
2022
pubmed:
11
3
2022
medline:
9
4
2022
Statut:
epublish
Résumé
Age-related macular degeneration (AMD) is an eye disease typically associated with the aging and can be classified into two types-namely, the exudative and the nonexudative AMD. Currently available treatments for exudative AMD use intravitreal injections, which are associated with high risk of infection that can lead to endophthalmitis, while no successful treatments yet exist for the nonexudative form of AMD. In addition to the pharmacologic therapies administered by intravitreal injection already approved by the Food and Drug Administration (FDA) in exudative AMD, there are some laser treatments approved that can be used in combination with the pharmacological therapies. In this review, we discuss the latest developments of treatment options for AMD. Relevant literature available from 1993 was used, which included original articles and reviews available in PubMed database and also information collected from Clinical Trials Gov website using "age-related macular degeneration" and "antiangiogenic therapies" as keywords. The clinical trials search was limited to ongoing trials from 2015 to date.
Identifiants
pubmed: 35269743
pii: ijms23052592
doi: 10.3390/ijms23052592
pmc: PMC8910030
pii:
doi:
Substances chimiques
Angiogenesis Inhibitors
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Portuguese Science and Technology Foundation (FCT) from the Ministry of Science and Technology (MCTES), European Social Fund (FSE)
ID : SFRH/BD/130555/2017, UIDB/04469/2020 (CEB strategic fund), UIDB/04033/2020 (CITAB)
Organisme : National Science Centre
ID : MINIATURA 4 (grant no: 2020/04/X/ST5/00789)
Organisme : Foundation for Polish Science
ID : START 2021 Program
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