Exercise and Training Regulation of Autophagy Markers in Human and Rat Skeletal Muscle.
LC3
autophagy
exercise
skeletal muscle
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
27 Feb 2022
27 Feb 2022
Historique:
received:
28
01
2022
revised:
20
02
2022
accepted:
25
02
2022
entrez:
10
3
2022
pubmed:
11
3
2022
medline:
9
4
2022
Statut:
epublish
Résumé
Autophagy is a key intracellular mechanism by which cells degrade old or dysfunctional proteins and organelles. In skeletal muscle, evidence suggests that exercise increases autophagosome content and autophagy flux. However, the exercise-induced response seems to differ between rodents and humans, and little is known about how different exercise prescription parameters may affect these results. The present study utilised skeletal muscle samples obtained from four different experimental studies using rats and humans. Here, we show that, following exercise, in the soleus muscle of Wistar rats, there is an increase in LC3B-I protein levels immediately after exercise (+109%), and a subsequent increase in LC3B-II protein levels 3 h into the recovery (+97%), despite no change in
Identifiants
pubmed: 35269762
pii: ijms23052619
doi: 10.3390/ijms23052619
pmc: PMC8910616
pii:
doi:
Substances chimiques
Biomarkers
0
Microtubule-Associated Proteins
0
RNA, Messenger
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
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