Prodrug-Based Targeting Approach for Inflammatory Bowel Diseases Therapy: Mechanistic Study of Phospholipid-Linker-Cyclosporine PLA
cyclosporine
drug targeting
inflammatory bowel disease
oral drug delivery
phospholipase A2
prodrug
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
28 Feb 2022
28 Feb 2022
Historique:
received:
29
12
2021
revised:
14
02
2022
accepted:
24
02
2022
entrez:
10
3
2022
pubmed:
11
3
2022
medline:
9
4
2022
Statut:
epublish
Résumé
Therapeutics with activity specifically at the inflamed sites throughout the gastrointestinal tract (GIT) would be a major advance in our therapeutic approach to inflammatory bowel disease (IBD). We aimed to develop the prodrug approach that can allow such site-specific drug delivery. Currently, using cyclosporine as a drug of choice in IBD is limited to the most severe cases due to substantial systemic toxicities and narrow therapeutic index of this drug. Previously, we synthesized a series of a phospholipid-linker-cyclosporine (PLC) prodrugs designed to exploit the overexpression of phospholipase A
Identifiants
pubmed: 35269813
pii: ijms23052673
doi: 10.3390/ijms23052673
pmc: PMC8910962
pii:
doi:
Substances chimiques
Phospholipids
0
Prodrugs
0
Cyclosporine
83HN0GTJ6D
Phospholipases A2
EC 3.1.1.4
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : United States-Israel Binational Science Foundation
ID : 2015365
Références
Int J Cancer. 1997 Jun 20;74(3):245-50
pubmed: 9221799
Curr Drug Targets. 2016;17(16):1940-1962
pubmed: 26212262
Pharmaceutics. 2020 Dec 02;12(12):
pubmed: 33276565
J Mol Graph. 1996 Feb;14(1):33-8, 27-8
pubmed: 8744570
N Engl J Med. 1994 Jun 30;330(26):1841-5
pubmed: 8196726
Scand J Clin Lab Invest. 1999 Jul;59(4):279-87
pubmed: 10463466
Pharmaceutics. 2020 Oct 29;12(11):
pubmed: 33137942
J Phys Chem B. 1998 Apr 30;102(18):3586-616
pubmed: 24889800
Mayo Clin Proc. 1992 Oct;67(10):981-90
pubmed: 1434859
PLoS One. 2016 Jun 23;11(6):e0158017
pubmed: 27336296
Gut. 2003 Feb;52(2):172-3
pubmed: 12524395
Int J Mol Sci. 2020 May 04;21(9):
pubmed: 32375338
J Control Release. 2007 May 14;119(1):86-93
pubmed: 17382425
Lancet. 2018 Dec 23;390(10114):2769-2778
pubmed: 29050646
World J Gastroenterol. 2014 Mar 28;20(12):3146-52
pubmed: 24696600
Science. 1990 Dec 14;250(4987):1563-6
pubmed: 2274788
J Control Release. 2020 Jun 10;322:486-508
pubmed: 32276004
Am J Gastroenterol. 1997 Sep;92(9):1424-8
pubmed: 9317057
N Engl J Med. 1991 Jan 31;324(5):333-4
pubmed: 1986292
Future Med Chem. 2019 Oct;11(19):2563-2571
pubmed: 31633401
Chem Phys Lipids. 2000 Oct;107(2):143-57
pubmed: 11090844
Am J Gastroenterol. 1997 Feb;92(2):289-92
pubmed: 9040208
Science. 1984 Dec 21;226(4681):1439-41
pubmed: 6334364
Gut. 1994 Nov;35(11):1593-8
pubmed: 7828979
Lancet. 1979 Nov 17;2(8151):1033-6
pubmed: 91781
Nat Rev Drug Discov. 2018 Aug;17(8):559-587
pubmed: 29700501
N Engl J Med. 2009 Nov 19;361(21):2066-78
pubmed: 19923578
N Engl J Med. 1984 Sep 13;311(11):728-9
pubmed: 6472359
Gut. 1997 Jan;40(1):95-101
pubmed: 9155583
Pharmaceutics. 2018 Nov 01;10(4):
pubmed: 30388756
Med Res Rev. 2019 Mar;39(2):579-607
pubmed: 30320896
Gut. 2004 Sep;53 Suppl 5:V1-16
pubmed: 15306569
Clin Rev Allergy Immunol. 2017 Jun;52(3):401-423
pubmed: 27515671
Biochemistry. 1996 Apr 9;35(14):4591-601
pubmed: 8605210
J Pharm Sci. 2010 Dec;99(12):4755-65
pubmed: 20821387
ChemMedChem. 2020 Sep 3;15(17):1639-1644
pubmed: 32618133
J Rheumatol. 1985 Apr;12(2):211-6
pubmed: 4032400
Biopolymers. 1983 Dec;22(12):2577-637
pubmed: 6667333
J Transplant. 2012;2012:230386
pubmed: 22263104
J Lipid Res. 2009 Apr;50 Suppl:S237-42
pubmed: 19011112
Pharmaceutics. 2019 Apr 16;11(4):
pubmed: 30995772
Drugs. 1993 Jun;45(6):953-1040
pubmed: 7691501
Am J Gastroenterol. 2016 Apr;111(4):477-91
pubmed: 26856754
Gut. 1995 Sep;37(3):380-5
pubmed: 7590434
Lancet Gastroenterol Hepatol. 2020 Jan;5(1):17-30
pubmed: 31648971
Eur J Pharm Sci. 2017 Oct 15;108:78-85
pubmed: 28627471
Biophys J. 1995 Dec;69(6):2558-62
pubmed: 8599662
J Control Release. 2008 Feb 18;126(1):1-9
pubmed: 18082281