Integrated GWAS and Gene Expression Suggest ORM1 as a Potential Regulator of Plasma Levels of Cell-Free DNA and Thrombosis Risk.
Journal
Thrombosis and haemostasis
ISSN: 2567-689X
Titre abrégé: Thromb Haemost
Pays: Germany
ID NLM: 7608063
Informations de publication
Date de publication:
Jun 2022
Jun 2022
Historique:
pubmed:
11
3
2022
medline:
7
7
2022
entrez:
10
3
2022
Statut:
ppublish
Résumé
Plasma cell-free DNA (cfDNA) is a surrogate marker of neutrophil extracellular traps (NETs) that contribute to immunothrombosis. There is growing interest about the mechanisms underlying NET formation and elevated cfDNA, but little is known about the factors involved. We aimed to identify genes involved in the regulation of cfDNA levels using data from the Genetic Analysis of Idiopathic Thrombophilia (GAIT-2) Project.Imputed genotypes, whole blood RNA-Seq data, and plasma cfDNA quantification were available for 935 of the GAIT-2 participants from 35 families with idiopathic thrombophilia. We performed heritability and GWAS analysis for cfDNA. The heritability of cfDNA was 0.26 (
Identifiants
pubmed: 35272364
doi: 10.1055/s-0041-1742169
pmc: PMC9251712
doi:
Substances chimiques
Cell-Free Nucleic Acids
0
ORM1 protein, human
0
Orosomucoid
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1027-1039Subventions
Organisme : PI14/00582
ID : Instituto de Salud Carlos III and Fondo de Investigación Sanitaria (ISCIII-FIS)
Organisme : PI17/00059
ID : Instituto de Salud Carlos III and Fondo de Investigación Sanitaria (ISCIII-FIS)
Organisme : SGR 1736, J.M.S
ID : Grupo Consolidado Generalitat de Catalunya
Organisme : FI2017B_00673
ID : Agència de Gestió d'ajuts Universitaris i de Recerca
Organisme : CP17/00142
ID : Miguel Servet contract from the ISCIII
Informations de copyright
The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).
Déclaration de conflit d'intérêts
None declared.
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