Evaluation of antithrombotic use and COVID-19 outcomes in a nationwide atrial fibrillation cohort.

Aged Anticoagulants / adverse effects Atrial Fibrillation / complications COVID-19 / epidemiology Female Fibrinolytic Agents Humans Risk Assessment Risk Factors Stroke / etiology Warfarin
COVID-19 atrial fibrillation drug monitoring electronic health records epidemiology

Journal

Heart (British Cardiac Society)
ISSN: 1468-201X
Titre abrégé: Heart
Pays: England
ID NLM: 9602087

Informations de publication

Date de publication:
25 05 2022
Historique:
received: 15 09 2021
accepted: 24 01 2022
pubmed: 12 3 2022
medline: 28 5 2022
entrez: 11 3 2022
Statut: epublish

Résumé

To evaluate antithrombotic (AT) use in individuals with atrial fibrillation (AF) and at high risk of stroke (CHA Individuals with AF and CHA From 972 971 individuals with AF (age 79 (±9.3), female 46.2%) and CHA Pre-existing AT use may be associated with lower odds of COVID-19 death and, while not evidence of causality, provides further incentive to improve AT coverage for eligible individuals with AF.

Identifiants

DOI: 10.1136/heartjnl-2021-320325 PMID: 35273122 PMC: PMC8931797
pubmed: 35273122
pii: heartjnl-2021-320325
doi: 10.1136/heartjnl-2021-320325
pmc: PMC8931797
doi:

Substances chimiques

Anticoagulants 0
Fibrinolytic Agents 0
Warfarin 5Q7ZVV76EI

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

923-931

Subventions

Organisme : Medical Research Council
ID : MR/L003120/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/K006584/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_PC_20059
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_PC_20051
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_PC_17214
Pays : United Kingdom
Organisme : Alzheimer's Society
ID : 171
Pays : United Kingdom
Organisme : British Heart Foundation
ID : SP/18/3/33801
Pays : United Kingdom

Commentaires et corrections

Type : CommentIn

Informations de copyright

© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY. Published by BMJ.

Déclaration de conflit d'intérêts

Competing interests: None declared.

Références

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Auteurs

Alex Handy (A)

Institute of Health Informatics, University College London, London, UK alex.handy.research@gmail.com.
ORCID: 0000-0002-3739-1530

Amitava Banerjee (A)

Institute of Health Informatics, University College London, London, UK.
University College London Hospitals National Health Service Trust, London, UK.
Barts Health National Health Service Trust, The Royal London Hospital, London, UK.
ORCID: 0000-0001-8741-3411

Angela M Wood (AM)

British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
British Heart Foundation Centre of Research Excellence, University of Cambridge, Cambridge, UK.
Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Cambridge, UK.
National Institute for Health Research Blood and Transplant Research Unit in Donor Health and Genomics, University of Cambridge, Cambridge, UK.
ORCID: 0000-0002-7937-304X

Caroline Dale (C)

Institute of Health Informatics, University College London, London, UK.

Cathie L M Sudlow (CLM)

British Heart Foundation Data Science Centre, Health Data Research UK, London, UK.
Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.
Usher Institute, Edinburgh Medical School, University of Edinburgh, Edinburgh, UK.
ORCID: 0000-0002-7725-7520

Christopher Tomlinson (C)

Institute of Health Informatics, University College London, London, UK.
University College London Hospitals National Health Service Trust, London, UK.
UKRI Centre for Doctoral Training in AI-enabled Healthcare Systems, University College London, London, UK.
National Institute for Health Research University College London Hospitals Biomedical Research Centre, University College London, London, UK.
ORCID: 0000-0002-0903-5395

Daniel Bean (D)

Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
NIHR Maudsley Biomedical Research Centre, South London and Maudsley National Health Service Trust, London, UK.
Health Data Research UK London, University College London, London, UK.
ORCID: 0000-0002-8594-7804

Johan H Thygesen (JH)

Institute of Health Informatics, University College London, London, UK.
ORCID: 0000-0002-7479-3459

Mehrdad A Mizani (MA)

Institute of Health Informatics, University College London, London, UK.

Michail Katsoulis (M)

Institute of Health Informatics, University College London, London, UK.
MRC Unit for Lifelong Health and Ageing and Centre for Longitudinal Studies, University College London, London, UK.
ORCID: 0000-0002-1756-9530

Rohan Takhar (R)

Institute of Health Informatics, University College London, London, UK.

Sam Hollings (S)

National Health Service Digital, Leeds, UK.

Spiros Denaxas (S)

Institute of Health Informatics, University College London, London, UK.
British Heart Foundation Data Science Centre, Health Data Research UK, London, UK.
National Institute for Health Research University College London Hospitals Biomedical Research Centre, University College London, London, UK.
British Heart Foundation Research Accelerator, University College London, London, UK.
ORCID: 0000-0001-9612-7791

Venexia Walker (V)

Bristol Medical School: Population Health Sciences, University of Bristol, Bristol, UK.

Richard Dobson (R)

Institute of Health Informatics, University College London, London, UK.
National Institute for Health Research University College London Hospitals Biomedical Research Centre, University College London, London, UK.
Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
NIHR Maudsley Biomedical Research Centre, South London and Maudsley National Health Service Trust, London, UK.
Health Data Research UK London, University College London, London, UK.
ORCID: 0000-0003-4224-9245

Reecha Sofat (R)

Institute of Health Informatics, University College London, London, UK.
Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK.
ORCID: 0000-0002-0242-6115

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Evaluation of antithrombotic use and COVID-19...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents hématologiques › Anticoagulants › Evaluation of antithrombotic use and COVID-19...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Troubles du rythme cardiaque › Fibrillation auriculaire › Evaluation of antithrombotic use and COVID-19...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Infections de l'appareil respiratoire › Pneumopathie infectieuse › Pneumopathie virale › COVID-19 › Evaluation of antithrombotic use and COVID-19...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents hématologiques › Fibrinolytiques › Evaluation of antithrombotic use and COVID-19...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Evaluation of antithrombotic use and COVID-19...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Probabilité › Risque › Appréciation des risques › Evaluation of antithrombotic use and COVID-19...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Probabilité › Risque › Facteurs de risque › Evaluation of antithrombotic use and COVID-19...
questionsmedicales.fr › Maladies cardiovasculaires › Maladies vasculaires › Angiopathies intracrâniennes › Accident vasculaire cérébral › Evaluation of antithrombotic use and COVID-19...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Benzopyranes › Coumarines › 4-Hydroxycoumarines › Warfarine › Evaluation of antithrombotic use and COVID-19...