Synthetic glycans control gut microbiome structure and mitigate colitis in mice.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
10 03 2022
10 03 2022
Historique:
received:
24
08
2021
accepted:
08
02
2022
entrez:
11
3
2022
pubmed:
12
3
2022
medline:
6
4
2022
Statut:
epublish
Résumé
Relative abundances of bacterial species in the gut microbiome have been linked to many diseases. Species of gut bacteria are ecologically differentiated by their abilities to metabolize different glycans, making glycan delivery a powerful way to alter the microbiome to promote health. Here, we study the properties and therapeutic potential of chemically diverse synthetic glycans (SGs). Fermentation of SGs by gut microbiome cultures results in compound-specific shifts in taxonomic and metabolite profiles not observed with reference glycans, including prebiotics. Model enteric pathogens grow poorly on most SGs, potentially increasing their safety for at-risk populations. SGs increase survival, reduce weight loss, and improve clinical scores in mouse models of colitis. Synthetic glycans are thus a promising modality to improve health through selective changes to the gut microbiome.
Identifiants
pubmed: 35273143
doi: 10.1038/s41467-022-28856-x
pii: 10.1038/s41467-022-28856-x
pmc: PMC8913648
doi:
Substances chimiques
Polysaccharides
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1244Subventions
Organisme : NIDDK NIH HHS
ID : P30 DK098722
Pays : United States
Informations de copyright
© 2022. The Author(s).
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