Fusobacterium nucleatum reduces METTL3-mediated m


Journal

Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555

Informations de publication

Date de publication:
10 03 2022
Historique:
received: 13 01 2021
accepted: 17 02 2022
entrez: 11 3 2022
pubmed: 12 3 2022
medline: 6 4 2022
Statut: epublish

Résumé

Microbiota-host interactions play critical roles in colorectal cancer (CRC) progression, however, the underlying mechanisms remain elusive. Here, we uncover that Fusobacterium nucleatum (F. nucleatum) induces a dramatic decline of m

Identifiants

pubmed: 35273176
doi: 10.1038/s41467-022-28913-5
pii: 10.1038/s41467-022-28913-5
pmc: PMC8913623
doi:

Substances chimiques

Methyltransferases EC 2.1.1.-
METTL3 protein, human EC 2.1.1.62

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

1248

Informations de copyright

© 2022. The Author(s).

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Auteurs

Shujie Chen (S)

Department of Cell Biology and Department of Gastroenterology of Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Department of Gastroenterology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Institute of Gastroenterology, Zhejiang University, Hangzhou, China.
Cancer Center, Zhejiang University, Hangzhou, China.

Lu Zhang (L)

Department of Cell Biology and Department of Gastroenterology of Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Institute of Gastroenterology, Zhejiang University, Hangzhou, China.
Cancer Center, Zhejiang University, Hangzhou, China.

Mengjie Li (M)

Department of Cell Biology and Department of Gastroenterology of Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Institute of Gastroenterology, Zhejiang University, Hangzhou, China.
Cancer Center, Zhejiang University, Hangzhou, China.

Ying Zhang (Y)

Department of Cell Biology and Department of Gastroenterology of Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Department of Gastroenterology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Institute of Gastroenterology, Zhejiang University, Hangzhou, China.
Cancer Center, Zhejiang University, Hangzhou, China.

Meng Sun (M)

Department of Cell Biology and Department of Gastroenterology of Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Institute of Gastroenterology, Zhejiang University, Hangzhou, China.
Cancer Center, Zhejiang University, Hangzhou, China.

Lingfang Wang (L)

Women's Hospital, Institute of Genetics, and Department of Environmental Medicine, Zhejiang University School of Medicine, Zhejiang, China.

Jiebo Lin (J)

Women's Hospital, Institute of Genetics, and Department of Environmental Medicine, Zhejiang University School of Medicine, Zhejiang, China.

Yun Cui (Y)

Department of Cell Biology and Department of Gastroenterology of Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Institute of Gastroenterology, Zhejiang University, Hangzhou, China.
Cancer Center, Zhejiang University, Hangzhou, China.

Qian Chen (Q)

Department of Cell Biology and Department of Gastroenterology of Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Institute of Gastroenterology, Zhejiang University, Hangzhou, China.
Cancer Center, Zhejiang University, Hangzhou, China.

Chenqi Jin (C)

Department of Cell Biology and Department of Gastroenterology of Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Institute of Gastroenterology, Zhejiang University, Hangzhou, China.
Cancer Center, Zhejiang University, Hangzhou, China.

Xiang Li (X)

Department of Cell Biology and Department of Gastroenterology of Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Institute of Gastroenterology, Zhejiang University, Hangzhou, China.
Cancer Center, Zhejiang University, Hangzhou, China.

Boya Wang (B)

Institute of Gastroenterology, Zhejiang University, Hangzhou, China.
Department of Pharmacy, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Hao Chen (H)

School of Medicine, Southern University of Science and Technology, Shenzhen, China.

Tianhua Zhou (T)

Department of Cell Biology and Department of Gastroenterology of Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China. tzhou@zju.edu.cn.
Institute of Gastroenterology, Zhejiang University, Hangzhou, China. tzhou@zju.edu.cn.
Cancer Center, Zhejiang University, Hangzhou, China. tzhou@zju.edu.cn.

Liangjing Wang (L)

Institute of Gastroenterology, Zhejiang University, Hangzhou, China. wangljzju@zju.edu.cn.
Cancer Center, Zhejiang University, Hangzhou, China. wangljzju@zju.edu.cn.
Department of Gastroenterology, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China. wangljzju@zju.edu.cn.

Chih-Hung Hsu (CH)

Women's Hospital, Institute of Genetics, and Department of Environmental Medicine, Zhejiang University School of Medicine, Zhejiang, China. ch_hsu@zju.edu.cn.

Wei Zhuo (W)

Department of Cell Biology and Department of Gastroenterology of Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China. wzhuo@zju.edu.cn.
Institute of Gastroenterology, Zhejiang University, Hangzhou, China. wzhuo@zju.edu.cn.
Cancer Center, Zhejiang University, Hangzhou, China. wzhuo@zju.edu.cn.

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Classifications MeSH