Divergent trajectories of antiviral memory after SARS-CoV-2 infection.


Journal

Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555

Informations de publication

Date de publication:
10 03 2022
Historique:
received: 15 06 2021
accepted: 17 02 2022
entrez: 11 3 2022
pubmed: 12 3 2022
medline: 5 4 2022
Statut: epublish

Résumé

The trajectories of acquired immunity to severe acute respiratory syndrome coronavirus 2 infection are not fully understood. We present a detailed longitudinal cohort study of UK healthcare workers prior to vaccination, presenting April-June 2020 with asymptomatic or symptomatic infection. Here we show a highly variable range of responses, some of which (T cell interferon-gamma ELISpot, N-specific antibody) wane over time, while others (spike-specific antibody, B cell memory ELISpot) are stable. We use integrative analysis and a machine-learning approach (SIMON - Sequential Iterative Modeling OverNight) to explore this heterogeneity. We identify a subgroup of participants with higher antibody responses and interferon-gamma ELISpot T cell responses, and a robust trajectory for longer term immunity associates with higher levels of neutralising antibodies against the infecting (Victoria) strain and also against variants B.1.1.7 (alpha) and B.1.351 (beta). These variable trajectories following early priming may define subsequent protection from severe disease from novel variants.

Identifiants

pubmed: 35273178
doi: 10.1038/s41467-022-28898-1
pii: 10.1038/s41467-022-28898-1
pmc: PMC8913789
doi:

Substances chimiques

Antibodies, Viral 0
Antiviral Agents 0
Spike Glycoprotein, Coronavirus 0
spike protein, SARS-CoV-2 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1251

Subventions

Organisme : Medical Research Council
ID : MR/L006588/1
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 204721/Z/16/Z
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 211153/Z/18/Z
Pays : United Kingdom
Organisme : Wellcome Trust
Pays : United Kingdom

Investigateurs

Lizzie Stafford (L)
Hibatullah Abuelgasim (H)
Ahmed Alhussni (A)
Carolina V Arancibia-Cárcamo (CV)
Martyna Borak (M)
Joseph Cutteridge (J)
Alexandra Deeks (A)
Lucy Denly (L)
Stavros Dimitriadis (S)
Shayan Fassih (S)
Thomas Foord (T)
Thomas Fordwoh (T)
Jennifer Holmes (J)
Bryn Horsington (B)
Sven Kerneis (S)
David Kim (D)
Katy Lillie (K)
Jordan Morrow (J)
Denise O'Donnell (D)
Thomas G Ritter (TG)
Beatrice Simmons (B)
Adan Taylor (A)
Sarah R Thomas (SR)
Yolanda Warren (Y)
Adam J R Watson (AJR)
Esme Weeks (E)
Robert Wilson (R)
Rebecca Young (R)
Christopher J A Duncan (CJA)
Shona C Moore (SC)
Rebecca Payne (R)
Alex Richter (A)
Sarah Rowland-Jones (S)
Alexander J Mentzer (AJ)
Mark Philip Cassar (MP)
Tao Dong (T)
Anastasia Fries (A)
Javier Gilbert-Jaramillo (J)
Ling-Pei Ho (LP)
Julian C Knight (JC)
Stefan Neubauer (S)
Yanchun Peng (Y)
Nayia Petousi (N)
Betty Raman (B)
Nick P Talbot (NP)

Informations de copyright

© 2022. The Author(s).

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Auteurs

Adriana Tomic (A)

Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK. info@adrianatomic.com.

Donal T Skelly (DT)

Peter Medawar Building for Pathogen Research, Nuffield Dept. of Clinical Medicine, University of Oxford, Oxford, UK.
Oxford University Hospitals NHS Foundation Trust, Oxford, UK.
Nuffield Dept of Clinical Neuroscience, University of Oxford, Oxford, UK.

Ane Ogbe (A)

Peter Medawar Building for Pathogen Research, Nuffield Dept. of Clinical Medicine, University of Oxford, Oxford, UK.

Daniel O'Connor (D)

Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK.
NIHR Oxford Biomedical Research Centre, Oxford, UK.

Matthew Pace (M)

Peter Medawar Building for Pathogen Research, Nuffield Dept. of Clinical Medicine, University of Oxford, Oxford, UK.

Emily Adland (E)

Peter Medawar Building for Pathogen Research, Nuffield Dept. of Clinical Medicine, University of Oxford, Oxford, UK.

Frances Alexander (F)

United Kingdom Health Security Agency, Porton Down, Wiltshire, England.

Mohammad Ali (M)

Peter Medawar Building for Pathogen Research, Nuffield Dept. of Clinical Medicine, University of Oxford, Oxford, UK.

Kirk Allott (K)

Department of Clinical Biochemistry, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.

M Azim Ansari (M)

Peter Medawar Building for Pathogen Research, Nuffield Dept. of Clinical Medicine, University of Oxford, Oxford, UK.

Sandra Belij-Rammerstorfer (S)

Jenner Institute, University of Oxford, Oxford, UK.

Sagida Bibi (S)

Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK.

Luke Blackwell (L)

Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK.

Anthony Brown (A)

Peter Medawar Building for Pathogen Research, Nuffield Dept. of Clinical Medicine, University of Oxford, Oxford, UK.

Helen Brown (H)

Peter Medawar Building for Pathogen Research, Nuffield Dept. of Clinical Medicine, University of Oxford, Oxford, UK.

Breeze Cavell (B)

United Kingdom Health Security Agency, Porton Down, Wiltshire, England.

Elizabeth A Clutterbuck (EA)

Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK.

Thushan de Silva (T)

The Florey Institute for Host-Pathogen Interactions and Department of Infection, Immunity and Cardiovascular Disease, Medical School, University of Sheffield, Sheffield, UK.

David Eyre (D)

Oxford University Hospitals NHS Foundation Trust, Oxford, UK.
Big Data Institute, Nuffield Dept. of Population Health, University of Oxford, Oxford, UK.

Sheila Lumley (S)

Peter Medawar Building for Pathogen Research, Nuffield Dept. of Clinical Medicine, University of Oxford, Oxford, UK.
Oxford University Hospitals NHS Foundation Trust, Oxford, UK.

Amy Flaxman (A)

Jenner Institute, University of Oxford, Oxford, UK.

James Grist (J)

Department of Physiology, Anatomy, and Genetics, University of Oxford, Oxford, UK.

Carl-Philipp Hackstein (CP)

Peter Medawar Building for Pathogen Research, Nuffield Dept. of Clinical Medicine, University of Oxford, Oxford, UK.

Rachel Halkerston (R)

United Kingdom Health Security Agency, Porton Down, Wiltshire, England.

Adam C Harding (AC)

James & Lillian Martin Centre, Sir William Dunn School of Pathology, University of Oxford, Oxford, UK.

Jennifer Hill (J)

Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK.
NIHR Oxford Biomedical Research Centre, Oxford, UK.

Tim James (T)

Department of Clinical Biochemistry, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.

Cecilia Jay (C)

Peter Medawar Building for Pathogen Research, Nuffield Dept. of Clinical Medicine, University of Oxford, Oxford, UK.

Síle A Johnson (SA)

Peter Medawar Building for Pathogen Research, Nuffield Dept. of Clinical Medicine, University of Oxford, Oxford, UK.
Oxford University Hospitals NHS Foundation Trust, Oxford, UK.
Oxford University Medical School, Medical Sciences Division, University of Oxford, Oxford, UK.

Barbara Kronsteiner (B)

Peter Medawar Building for Pathogen Research, Nuffield Dept. of Clinical Medicine, University of Oxford, Oxford, UK.
Oxford Centre For Global Health Research, Nuffield Dept. of Clinical Medicine, University of Oxford, Oxford, UK.

Yolanda Lie (Y)

Monogram Biosciences LabCorp, San Francisco, CA, USA.

Aline Linder (A)

Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK.
NIHR Oxford Biomedical Research Centre, Oxford, UK.

Stephanie Longet (S)

United Kingdom Health Security Agency, Porton Down, Wiltshire, England.
Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.

Spyridoula Marinou (S)

Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK.
NIHR Oxford Biomedical Research Centre, Oxford, UK.

Philippa C Matthews (PC)

Peter Medawar Building for Pathogen Research, Nuffield Dept. of Clinical Medicine, University of Oxford, Oxford, UK.
Oxford University Hospitals NHS Foundation Trust, Oxford, UK.
NIHR Oxford Biomedical Research Centre, Oxford, UK.

Jack Mellors (J)

United Kingdom Health Security Agency, Porton Down, Wiltshire, England.

Christos Petropoulos (C)

Monogram Biosciences LabCorp, San Francisco, CA, USA.

Patpong Rongkard (P)

Peter Medawar Building for Pathogen Research, Nuffield Dept. of Clinical Medicine, University of Oxford, Oxford, UK.
Mahidol-Oxford Tropical Medicine Research Unit, Mahidol University, Bangkok, Thailand.

Cynthia Sedik (C)

Monogram Biosciences LabCorp, San Francisco, CA, USA.

Laura Silva-Reyes (L)

Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK.
NIHR Oxford Biomedical Research Centre, Oxford, UK.

Holly Smith (H)

Jenner Institute, University of Oxford, Oxford, UK.

Lisa Stockdale (L)

Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK.
NIHR Oxford Biomedical Research Centre, Oxford, UK.

Stephen Taylor (S)

United Kingdom Health Security Agency, Porton Down, Wiltshire, England.

Stephen Thomas (S)

United Kingdom Health Security Agency, Porton Down, Wiltshire, England.

Timothy Tipoe (T)

Peter Medawar Building for Pathogen Research, Nuffield Dept. of Clinical Medicine, University of Oxford, Oxford, UK.

Lance Turtle (L)

HPRU in Emerging and Zoonotic Infections, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK.
Tropical and Infectious Disease Unit, Liverpool University Hospitals NHS Foundation Trust (a member of Liverpool Health Partners), Liverpool, UK.

Vinicius Adriano Vieira (VA)

Peter Medawar Building for Pathogen Research, Department of Paediatrics, University of Oxford, Oxford, UK.

Terri Wrin (T)

Monogram Biosciences LabCorp, San Francisco, CA, USA.

Andrew J Pollard (AJ)

Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK.
NIHR Oxford Biomedical Research Centre, Oxford, UK.

Teresa Lambe (T)

Jenner Institute, University of Oxford, Oxford, UK.

Chris P Conlon (CP)

Nuffield Department of Medicine, University of Oxford, Oxford, UK.

Katie Jeffery (K)

Oxford University Hospitals NHS Foundation Trust, Oxford, UK.
Radcliffe Department of Medicine, University of Oxford, Oxford, UK.

Simon Travis (S)

Oxford University Hospitals NHS Foundation Trust, Oxford, UK.
Translational Gastroenterology Unit, Nuffield Department of Medicine, University of Oxford, Oxford, UK.

Philip Goulder (P)

Peter Medawar Building for Pathogen Research, Department of Paediatrics, University of Oxford, Oxford, UK.

John Frater (J)

Peter Medawar Building for Pathogen Research, Nuffield Dept. of Clinical Medicine, University of Oxford, Oxford, UK.
Oxford University Hospitals NHS Foundation Trust, Oxford, UK.

Alex J Mentzer (AJ)

Oxford University Hospitals NHS Foundation Trust, Oxford, UK.
Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.

Lizzie Stafford (L)

Nuffield Department of Medicine, University of Oxford, Oxford, UK.

Miles W Carroll (MW)

United Kingdom Health Security Agency, Porton Down, Wiltshire, England.
Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.

William S James (WS)

James & Lillian Martin Centre, Sir William Dunn School of Pathology, University of Oxford, Oxford, UK.

Paul Klenerman (P)

Peter Medawar Building for Pathogen Research, Nuffield Dept. of Clinical Medicine, University of Oxford, Oxford, UK.
Oxford University Hospitals NHS Foundation Trust, Oxford, UK.
NIHR Oxford Biomedical Research Centre, Oxford, UK.
Translational Gastroenterology Unit, Nuffield Department of Medicine, University of Oxford, Oxford, UK.

Eleanor Barnes (E)

Peter Medawar Building for Pathogen Research, Nuffield Dept. of Clinical Medicine, University of Oxford, Oxford, UK. ellie.barnes@ndm.ox.ac.uk.
Oxford University Hospitals NHS Foundation Trust, Oxford, UK. ellie.barnes@ndm.ox.ac.uk.
NIHR Oxford Biomedical Research Centre, Oxford, UK. ellie.barnes@ndm.ox.ac.uk.
Translational Gastroenterology Unit, Nuffield Department of Medicine, University of Oxford, Oxford, UK. ellie.barnes@ndm.ox.ac.uk.

Christina Dold (C)

Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK.
NIHR Oxford Biomedical Research Centre, Oxford, UK.

Susanna J Dunachie (SJ)

Peter Medawar Building for Pathogen Research, Nuffield Dept. of Clinical Medicine, University of Oxford, Oxford, UK.
Oxford University Hospitals NHS Foundation Trust, Oxford, UK.
Oxford Centre For Global Health Research, Nuffield Dept. of Clinical Medicine, University of Oxford, Oxford, UK.
Mahidol-Oxford Tropical Medicine Research Unit, Mahidol University, Bangkok, Thailand.

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