Metabolic tricks of cancer cells.
Cancer metabolism
Cell death
Glutaminolysis
Metabolic symbiosis
Mitochondrial bioenergetics
Warburg effect
Journal
Biochimica et biophysica acta. Reviews on cancer
ISSN: 1879-2561
Titre abrégé: Biochim Biophys Acta Rev Cancer
Pays: Netherlands
ID NLM: 9806362
Informations de publication
Date de publication:
05 2022
05 2022
Historique:
received:
29
10
2021
revised:
11
02
2022
accepted:
26
02
2022
pubmed:
12
3
2022
medline:
9
6
2022
entrez:
11
3
2022
Statut:
ppublish
Résumé
One of the characteristics of cancer cells important for tumorigenesis is their metabolic plasticity. Indeed, in various stress conditions, cancer cells can reshape their metabolic pathways to support the increased energy request due to continuous growth and rapid proliferation. Moreover, selective pressures in the tumor microenvironment, such as hypoxia, acidosis, and competition for resources, force cancer cells to adapt by complete reorganization of their metabolism. In this review, we highlight the characteristics of cancer metabolism and discuss its clinical significance, since overcoming metabolic plasticity of cancer cells is a key objective of modern cancer therapeutics and a better understanding of metabolic reprogramming may lead to the identification of possible targets for cancer therapy.
Identifiants
pubmed: 35276232
pii: S0304-419X(22)00030-0
doi: 10.1016/j.bbcan.2022.188705
pii:
doi:
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
188705Informations de copyright
Copyright © 2022 Elsevier B.V. All rights reserved.