Interrogating the function of GABA
Journal
Current opinion in pharmacology
ISSN: 1471-4973
Titre abrégé: Curr Opin Pharmacol
Pays: England
ID NLM: 100966133
Informations de publication
Date de publication:
04 2022
04 2022
Historique:
received:
28
11
2021
revised:
21
01
2022
accepted:
25
01
2022
pubmed:
12
3
2022
medline:
12
4
2022
entrez:
11
3
2022
Statut:
ppublish
Résumé
To better understand neural circuits and behavior, microbial opsins have been developed as optogenetic tools for stimulating or inhibiting action potentials with high temporal and spatial precision. However, if we seek a more reductionist understanding of how neuronal circuits operate, we also need high-resolution tools for perturbing the function of synapses. By combining photochemical tools and molecular biology, a wide variety of light-regulated neurotransmitter receptors have been developed, enabling photo-control of excitatory, inhibitory, and modulatory synaptic transmission. Here we focus on photo-control of GABA
Identifiants
pubmed: 35276498
pii: S1471-4892(22)00024-8
doi: 10.1016/j.coph.2022.102198
pii:
doi:
Substances chimiques
Ligands
0
Receptors, GABA-A
0
gamma-Aminobutyric Acid
56-12-2
Types de publication
Journal Article
Review
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
102198Subventions
Organisme : NINDS NIH HHS
ID : R01 NS100911
Pays : United States
Organisme : NEI NIH HHS
ID : R01 EY024334
Pays : United States
Organisme : NEI NIH HHS
ID : P30 EY003176
Pays : United States
Informations de copyright
Copyright © 2022 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Conflict of interest statement Nothing declared.