The Ketogenic Diet: Is It an Answer for Sarcopenic Obesity?
cytokine
fatty liver
gut microbiota
ketogenic diet
physical inactivity
sarcopenia
visceral adipose tissue (VAT)
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
30 Jan 2022
30 Jan 2022
Historique:
received:
12
12
2021
revised:
02
01
2022
accepted:
10
01
2022
entrez:
12
3
2022
pubmed:
13
3
2022
medline:
16
3
2022
Statut:
epublish
Résumé
This review aims to define the effectiveness of the ketogenic diet (KD) for the management of sarcopenic obesity. As the combination of sarcopenia and obesity appears to have multiple negative metabolic effects, this narrative review discusses the effects of the ketogenic diet as a possible synergic intervention to decrease visceral adipose tissue (VAT) and fatty infiltration of the liver as well as modulate and improve the gut microbiota, inflammation and body composition. The results of this review support the evidence that the KD improves metabolic health and expands adipose tissue γδ T cells that are important for glycaemia control during obesity. The KD is also a therapeutic option for individuals with sarcopenic obesity due to its positive effect on VAT, adipose tissue, cytokines such as blood biochemistry, gut microbiota, and body composition. However, the long-term effect of a KD on these outcomes requires further investigations before general recommendations can be made.
Identifiants
pubmed: 35276979
pii: nu14030620
doi: 10.3390/nu14030620
pmc: PMC8838342
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
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