The Role of Gut Microbiota and Metabolites in Obesity-Associated Chronic Gastrointestinal Disorders.
CRC
IBD
SCFAs
gut microbiota
obesity
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
31 Jan 2022
31 Jan 2022
Historique:
received:
22
11
2021
revised:
13
01
2022
accepted:
28
01
2022
entrez:
12
3
2022
pubmed:
13
3
2022
medline:
16
3
2022
Statut:
epublish
Résumé
The gut microbiota is a complex community of microorganisms that has become a new focus of attention due to its association with numerous human diseases. Research over the last few decades has shown that the gut microbiota plays a considerable role in regulating intestinal homeostasis, and disruption to the microbial community has been linked to chronic disease conditions such as inflammatory bowel disease (IBD), colorectal cancer (CRC), and obesity. Obesity has become a global pandemic, and its prevalence is increasing worldwide mostly in Western countries due to a sedentary lifestyle and consumption of high-fat/high-sugar diets. Obesity-mediated gut microbiota alterations have been associated with the development of IBD and IBD-induced CRC. This review highlights how obesity-associated dysbiosis can lead to the pathogenesis of IBD and CRC with a special focus on mechanisms of altered absorption of short-chain fatty acids (SCFAs).
Identifiants
pubmed: 35276983
pii: nu14030624
doi: 10.3390/nu14030624
pmc: PMC8838694
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIH HHS
ID : DK-67420
Pays : United States
Organisme : NIH HHS
ID : DK-108054
Pays : United States
Organisme : NIH HHS
ID : P20GM121299-01A1
Pays : United States
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