Differences in the microbial profiles of early stage endometrial cancers between Black and White women.
Endometrial cancer
Race disparities
Uterine microbiome
Journal
Gynecologic oncology
ISSN: 1095-6859
Titre abrégé: Gynecol Oncol
Pays: United States
ID NLM: 0365304
Informations de publication
Date de publication:
05 2022
05 2022
Historique:
received:
20
01
2022
revised:
24
02
2022
accepted:
27
02
2022
pubmed:
13
3
2022
medline:
6
5
2022
entrez:
12
3
2022
Statut:
ppublish
Résumé
Black women suffer a higher mortality from endometrial cancer (EC) than White women. Potential biological causes for this disparity include a higher prevalence of obesity and more lethal histologic/molecular subtypes. We hypothesize that another biological factor driving this racial disparity could be the EC microbiome. Banked tumor specimens of postmenopausal, Black and White women undergoing hysterectomy for early stage endometrioid EC were identified. The microbiota of the tumors were characterized by bacterial 16S rRNA sequencing. The microbial component of endometrioid ECs in The Cancer Genome Atlas (TCGA) database were assessed for comparison. 95 early stage ECs were evaluated: 23 Black (24%) and 72 White (76%). Microbial diversity was increased (p < 0.001), and Firmicutes, Cyanobacteria and OD1 phyla abundance was higher in tumors from Black versus White women (p < 0.001). Genus level abundance of Dietzia and Geobacillus were found to be lower in tumors of obese Black versus obese White women (p < 0.001). Analysis of early stage ECs in TCGA found that microbial diversity was higher in ECs from Black versus White women (p < 0.05). When comparing ECs from obese Black versus obese White women, 5 bacteria distributions were distinct, with higher abundance of Lactobacillus acidophilus in ECs from Black women being the most striking difference. Similarly in TCGA, Dietzia and Geobacillus were more common in ECs from White women compared to Black. Increased microbial diversity and the distinct microbial profiles between ECs of obese Black versus obese White women suggests that intra-tumoral bacteria may contribute to EC disparities and pathogenesis.
Identifiants
pubmed: 35277280
pii: S0090-8258(22)00142-1
doi: 10.1016/j.ygyno.2022.02.021
pmc: PMC9093563
mid: NIHMS1791538
pii:
doi:
Substances chimiques
RNA, Ribosomal, 16S
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
248-256Subventions
Organisme : NIEHS NIH HHS
ID : P30 ES010126
Pays : United States
Organisme : NCI NIH HHS
ID : R21 CA220269
Pays : United States
Organisme : NCI NIH HHS
ID : T32 CA244125
Pays : United States
Informations de copyright
Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare no competing financial interest for this manuscript.
Références
Ann N Y Acad Sci. 2020 Feb;1461(1):37-52
pubmed: 31087391
Nat Rev Cancer. 2002 Jan;2(1):28-37
pubmed: 11902583
Cell Death Differ. 2018 Mar;25(3):460-470
pubmed: 29238070
Nat Commun. 2020 Jul 14;11(1):3514
pubmed: 32665548
Front Microbiol. 2017 Nov 07;8:2114
pubmed: 29163406
Appl Environ Microbiol. 2006 Jul;72(7):5069-72
pubmed: 16820507
Am J Obstet Gynecol. 2016 Dec;215(6):684-703
pubmed: 27717732
Appl Microbiol Biotechnol. 2018 Apr;102(7):3095-3104
pubmed: 29497795
Nat Prod Rep. 2002 Apr;19(2):133-47
pubmed: 12013276
PLoS One. 2017 Nov 30;12(11):e0188873
pubmed: 29190829
Infect Immun. 1999 Oct;67(10):5170-5
pubmed: 10496892
Cancer Med. 2019 Nov;8(16):6904-6914
pubmed: 31568654
Science. 2012 Oct 5;338(6103):120-3
pubmed: 22903521
J Exp Clin Cancer Res. 2020 Aug 18;39(1):163
pubmed: 32811566
Int J Cancer. 2018 Dec 1;143(11):2668-2676
pubmed: 29923185
PLoS Comput Biol. 2009 Apr;5(4):e1000352
pubmed: 19360128
Microbiome. 2017 Jan 25;5(1):9
pubmed: 28118849
Proc Natl Acad Sci U S A. 2020 Mar 31;117(13):7374-7381
pubmed: 32170007
Nature. 2006 Dec 21;444(7122):1027-31
pubmed: 17183312
Am J Obstet Gynecol. 2011 Apr;204(4):305.e1-7
pubmed: 21272848
Cancer Epidemiol Biomarkers Prev. 2015 Sep;24(9):1407-15
pubmed: 26290568
ISME J. 2007 Jun;1(2):121-33
pubmed: 18043622
Genome Med. 2016 Nov 25;8(1):122
pubmed: 27884207
Br J Cancer. 2020 Feb;122(3):306-314
pubmed: 31708575
Nat Biotechnol. 2020 Jun;38(6):685-688
pubmed: 32483366
Science. 2015 Apr 3;348(6230):80-6
pubmed: 25838377
Cell Host Microbe. 2017 Feb 8;21(2):195-207
pubmed: 28111202
CA Cancer J Clin. 2021 Jan;71(1):7-33
pubmed: 33433946
Lancet. 2013 Sep 7;382(9895):889-99
pubmed: 23618600
J Biol Chem. 2006 Sep 1;281(35):25054-61
pubmed: 16831864
Int J Mol Sci. 2021 May 26;22(11):
pubmed: 34073257
Proc Natl Acad Sci U S A. 2011 Mar 15;108 Suppl 1:4680-7
pubmed: 20534435
Microb Ecol Health Dis. 2015 May 29;26:27663
pubmed: 26028277
Sci Rep. 2019 Dec 16;9(1):19213
pubmed: 31844128
Gynecol Oncol. 2020 Nov;159(2):299-308
pubmed: 32933758
J Sci Food Agric. 2016 Jul;96(9):2952-62
pubmed: 26692250
Nat Protoc. 2020 Mar;15(3):799-821
pubmed: 31942082
Oncogene. 2018 Oct;37(43):5766-5779
pubmed: 29925861
Adv Food Nutr Res. 2018;83:151-194
pubmed: 29477221
Cancer Discov. 2022 Jan;12(1):31-46
pubmed: 35022204
Sci Rep. 2017 Sep 14;7(1):11590
pubmed: 28912574
Nat Methods. 2010 May;7(5):335-6
pubmed: 20383131
N Engl J Med. 2003 Apr 24;348(17):1625-38
pubmed: 12711737
Front Immunol. 2018 Mar 02;9:208
pubmed: 29552006
Gynecol Oncol. 2014 Apr;133(1):28-32
pubmed: 24680588
Inflammation. 2013 Feb;36(1):169-76
pubmed: 22923003