Relaxivity properties of magnetoferritin: The iron loading effect.
Contrast agent
Iron oxide nanoparticles
Magnetic resonance imaging
Magnetoferritin
Relaxivity
Journal
Journal of bioscience and bioengineering
ISSN: 1347-4421
Titre abrégé: J Biosci Bioeng
Pays: Japan
ID NLM: 100888800
Informations de publication
Date de publication:
May 2022
May 2022
Historique:
received:
07
09
2021
revised:
11
01
2022
accepted:
11
01
2022
pubmed:
13
3
2022
medline:
14
4
2022
entrez:
12
3
2022
Statut:
ppublish
Résumé
Self-assembling ferritin protein cages have been used as a template for magnetic iron oxide nanoparticle synthesis within its 8 nm cavity to be explored as a potential magnetic resonance imaging contrast agent. Here in, magnetic nanocores with various iron content were successfully synthesized using recombinant human H-chain ferritin (HFn) by a controlled mineralization reaction. r1 and r2 relaxivities of the synthesized magnetoferritin nanoparticles were measured and the effect of iron loading factor on the r1 and r2 relaxivity was investigated by using a quite large range of 10 different iron loadings per protein cage (500-5000) at 90 MHz and 300 MHz. The sample with the highest iron loading of 5329 Fe/cage has r2 value of 165.2 mM
Identifiants
pubmed: 35277341
pii: S1389-1723(22)00005-6
doi: 10.1016/j.jbiosc.2022.01.005
pii:
doi:
Substances chimiques
Contrast Media
0
Oxides
0
magnetoferritin
0
Ferritins
9007-73-2
Apoferritins
9013-31-4
Iron
E1UOL152H7
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
474-480Informations de copyright
Copyright © 2022 The Society for Biotechnology, Japan. Published by Elsevier B.V. All rights reserved.