Epigenome-wide association study and epigenetic age acceleration associated with cigarette smoking among Costa Rican adults.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
11 03 2022
11 03 2022
Historique:
received:
03
12
2021
accepted:
03
03
2022
entrez:
12
3
2022
pubmed:
13
3
2022
medline:
27
4
2022
Statut:
epublish
Résumé
Smoking-associated DNA methylation (DNAm) signatures are reproducible among studies of mostly European descent, with mixed evidence if smoking accelerates epigenetic aging and its relationship to longevity. We evaluated smoking-associated DNAm signatures in the Costa Rican Study on Longevity and Healthy Aging (CRELES), including participants from the high longevity region of Nicoya. We measured genome-wide DNAm in leukocytes, tested Epigenetic Age Acceleration (EAA) from five clocks and estimates of telomere length (DNAmTL), and examined effect modification by the high longevity region. 489 participants had a mean (SD) age of 79.4 (10.8) years, and 18% were from Nicoya. Overall, 7.6% reported currently smoking, 35% were former smokers, and 57.4% never smoked. 46 CpGs and five regions (e.g. AHRR, SCARNA6/SNORD39, SNORA20, and F2RL3) were differentially methylated for current smokers. Former smokers had increased Horvath's EAA (1.69-years; 95% CI 0.72, 2.67), Hannum's EAA (0.77-years; 95% CI 0.01, 1.52), GrimAge (2.34-years; 95% CI1.66, 3.02), extrinsic EAA (1.27-years; 95% CI 0.34, 2.21), intrinsic EAA (1.03-years; 95% CI 0.12, 1.94) and shorter DNAmTL (- 0.04-kb; 95% CI - 0.08, - 0.01) relative to non-smokers. There was no evidence of effect modification among residents of Nicoya. Our findings recapitulate previously reported and novel smoking-associated DNAm changes in a Latino cohort.
Identifiants
pubmed: 35277542
doi: 10.1038/s41598-022-08160-w
pii: 10.1038/s41598-022-08160-w
pmc: PMC8917214
doi:
Substances chimiques
DNA
9007-49-2
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
4277Subventions
Organisme : NIEHS NIH HHS
ID : R01ES031259
Pays : United States
Organisme : NIA NIH HHS
ID : R03AG06706
Pays : United States
Organisme : NIA NIH HHS
ID : 2P30AG012839
Pays : United States
Organisme : NIMHD NIH HHS
ID : R21MD013296
Pays : United States
Organisme : NIMHD NIH HHS
ID : R21MD013296
Pays : United States
Organisme : NIMHD NIH HHS
ID : R01 MD011721
Pays : United States
Informations de copyright
© 2022. The Author(s).
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