Pharmacokinetic-pharmacodynamic relationships of pour-on administered eprinomectin in nematode-infected lactating female and male castrated dairy breed goats.
Eprinomectin
Goat
Lactating
Pharmacokinetic-pharmacodynamic (PK-PD)
Journal
Parasitology research
ISSN: 1432-1955
Titre abrégé: Parasitol Res
Pays: Germany
ID NLM: 8703571
Informations de publication
Date de publication:
May 2022
May 2022
Historique:
received:
04
02
2022
accepted:
07
03
2022
pubmed:
13
3
2022
medline:
13
4
2022
entrez:
12
3
2022
Statut:
ppublish
Résumé
Eprinomectin (EPM), a macrocyclic lactone with low excretion in milk and high efficacy against endoparasites and ectoparasites, is widely used in veterinary medicine. In this paper, EPM pharmacokinetics and anthelmintic efficacy previously established in one study with lactating female goats and three studies with male castrated growing dairy breed goats (all with induced mixed adult gastrointestinal nematode parasitism and treated with a single 1-mg/kg pour-on administration of EPM) were retrospectively evaluated using pharmacokinetic-pharmacodynamic (PK-PD) modeling. The PK-PD analyses between EPM exposure (C
Identifiants
pubmed: 35277753
doi: 10.1007/s00436-022-07483-x
pii: 10.1007/s00436-022-07483-x
pmc: PMC8993713
doi:
Substances chimiques
Anthelmintics
0
Ivermectin
70288-86-7
eprinomectin
75KP30FD8O
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1533-1538Informations de copyright
© 2022. The Author(s).
Références
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