Schwann cells contribute to keloid formation.
Extracellular matrix
Keloid
Macrophage
Schwann cell
Single-cell RNA sequencing
Journal
Matrix biology : journal of the International Society for Matrix Biology
ISSN: 1569-1802
Titre abrégé: Matrix Biol
Pays: Netherlands
ID NLM: 9432592
Informations de publication
Date de publication:
04 2022
04 2022
Historique:
received:
27
08
2021
revised:
27
01
2022
accepted:
04
03
2022
pubmed:
13
3
2022
medline:
13
4
2022
entrez:
12
3
2022
Statut:
ppublish
Résumé
Keloids are disfiguring, hypertrophic scars with yet poorly understood pathomechanisms, which could lead to severe functional impairments. Here we analyzed the characteristics of keloidal cells by single cell sequencing and discovered the presence of an abundant population of Schwann cells that persisted in the hypertrophic scar tissue after wound healing. In contrast to normal skin, keloidal Schwann cells show a unique, pro-fibrotic phenotype. Our data support the hypothesis that keloidal Schwann cells contribute to the formation of the extracellular matrix and are able to affect M2 polarization of macrophages. Indeed, we show that macrophages in keloids predominantly display a M2 polarization and produce factors that inhibit Schwann cell differentiation. This study suggests the contribution of a Schwann cell - macrophage cross-talk to the continuous expansion of keloids, and that targeting Schwann cells might represent an interesting novel treatment option for keloids.
Identifiants
pubmed: 35278628
pii: S0945-053X(22)00033-6
doi: 10.1016/j.matbio.2022.03.001
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
55-76Informations de copyright
Copyright © 2022 The Author(s). Published by Elsevier B.V. All rights reserved.