Podocyte

GSNOR S-nitrosylation VEGF knockdown diabetic kidney disease diffuse glomerulosclerosis laminin β3-integrin

Journal

Frontiers in pharmacology
ISSN: 1663-9812
Titre abrégé: Front Pharmacol
Pays: Switzerland
ID NLM: 101548923

Informations de publication

Date de publication:
2021
Historique:
received: 03 10 2021
accepted: 13 12 2021
entrez: 14 3 2022
pubmed: 15 3 2022
medline: 15 3 2022
Statut: epublish

Résumé

Vascular endothelial growth factor-a (VEGF-A) and nitric oxide (NO) are essential for glomerular filtration barrier homeostasis, and are dysregulated in diabetic kidney disease (DKD). While NO availability is consistently low in diabetes, both high and low VEGF-A have been reported in patients with DKD. Here we examined the effect of inducible podocyte

Identifiants

pubmed: 35280251
doi: 10.3389/fphar.2021.788886
pii: 788886
pmc: PMC8906751
doi:

Types de publication

Journal Article

Langues

eng

Pagination

788886

Subventions

Organisme : NIDDK NIH HHS
ID : P30 DK079310
Pays : United States

Informations de copyright

Copyright © 2022 Veron, Aggarwal, Li, Moeckel, Kashgarian and Tufro.

Déclaration de conflit d'intérêts

Author PA is currently employed by the company Janssen Biopharma. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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Auteurs

Delma Veron (D)

Department of Pediatrics, Yale University School of Medicine, Malvern, PA, United States.

Pardeep K Aggarwal (PK)

Department of Pediatrics, Yale University School of Medicine, Malvern, PA, United States.

Qi Li (Q)

Department of Pediatrics, Yale University School of Medicine, Malvern, PA, United States.
Department of Pathology, Yale University School of Medicine, New Haven, CT, United States.

Gilbert Moeckel (G)

Department of Pathology, Yale University School of Medicine, New Haven, CT, United States.

Michael Kashgarian (M)

Department of Pathology, Yale University School of Medicine, New Haven, CT, United States.

Alda Tufro (A)

Department of Pediatrics, Yale University School of Medicine, Malvern, PA, United States.
Department of Cell and Molecular Physiology, Yale University School of Medicine, New Haven, CT, United States.

Classifications MeSH