Evaluation of mid- and long-term impact of COVID-19 on male fertility through evaluating semen parameters.
Coronavirus disease 2019 (COVID-19)
male fertility
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
sperm quality
Journal
Translational andrology and urology
ISSN: 2223-4691
Titre abrégé: Transl Androl Urol
Pays: China
ID NLM: 101581119
Informations de publication
Date de publication:
Feb 2022
Feb 2022
Historique:
received:
17
10
2021
accepted:
11
01
2022
entrez:
14
3
2022
pubmed:
15
3
2022
medline:
15
3
2022
Statut:
ppublish
Résumé
The coronavirus disease 2019 (COVID-19) has spread worldwide with alarming levels of spread and severity. The distribution of angiotensin converting enzyme 2 (ACE2) and transmembrane protease serine 2 (TMPRSS2) from bioinformatics evidence, the autopsy report for COVID-19 and the published study on sperm quality indicated COVID-19 could have a negative impact on male fertility. However, whether the negative impact of COVID-19 on male fertility is persistent remains unknown, which requires long-term follow-up investigation. Semen samples were collected from 36 male COVID-19 patients with a median recovery time of 177.5 days and 45 control subjects. Then, analysis of sperm quality and alterations of total sperm number with recovery time were performed. There was no significant difference in semen parameters between male recovered patients and control subjects. And the comparisons of semen parameters between first follow-up and second follow-up revealed no significant difference. In addition, we explored the alterations of sperm count with recovery time. It showed that the group with recovery time of ≥120 and <150 days had a significantly lower total sperm number than controls while the other two groups with recovery time of ≥150 days displayed no significance with controls, and total sperm number showed a significant decline after a recovery time of 90 days and an improving trend after a recovery time of about 150 days. The sperm quality of COVID-19 recovered patients improved after a recovery time of nearly half a year, while the total sperm number showed an improvement after a recovery time of about 150 days. COVID-19 patients should pay close attention to the quality of semen, and might be considered to be given medical interventions if necessary within about two months after recovery, in order to improve the fertility of male patients as soon as possible.
Sections du résumé
Background
UNASSIGNED
The coronavirus disease 2019 (COVID-19) has spread worldwide with alarming levels of spread and severity. The distribution of angiotensin converting enzyme 2 (ACE2) and transmembrane protease serine 2 (TMPRSS2) from bioinformatics evidence, the autopsy report for COVID-19 and the published study on sperm quality indicated COVID-19 could have a negative impact on male fertility. However, whether the negative impact of COVID-19 on male fertility is persistent remains unknown, which requires long-term follow-up investigation.
Methods
UNASSIGNED
Semen samples were collected from 36 male COVID-19 patients with a median recovery time of 177.5 days and 45 control subjects. Then, analysis of sperm quality and alterations of total sperm number with recovery time were performed.
Results
UNASSIGNED
There was no significant difference in semen parameters between male recovered patients and control subjects. And the comparisons of semen parameters between first follow-up and second follow-up revealed no significant difference. In addition, we explored the alterations of sperm count with recovery time. It showed that the group with recovery time of ≥120 and <150 days had a significantly lower total sperm number than controls while the other two groups with recovery time of ≥150 days displayed no significance with controls, and total sperm number showed a significant decline after a recovery time of 90 days and an improving trend after a recovery time of about 150 days.
Conclusions
UNASSIGNED
The sperm quality of COVID-19 recovered patients improved after a recovery time of nearly half a year, while the total sperm number showed an improvement after a recovery time of about 150 days. COVID-19 patients should pay close attention to the quality of semen, and might be considered to be given medical interventions if necessary within about two months after recovery, in order to improve the fertility of male patients as soon as possible.
Identifiants
pubmed: 35280660
doi: 10.21037/tau-21-922
pii: tau-11-02-159
pmc: PMC8899150
doi:
Types de publication
Journal Article
Langues
eng
Pagination
159-167Informations de copyright
2022 Translational Andrology and Urology. All rights reserved.
Déclaration de conflit d'intérêts
Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://tau.amegroups.com/article/view/10.21037/tau-21-922/coif). The authors have no conflicts of interest to declare.
Références
Lancet. 2020 Feb 22;395(10224):565-574
pubmed: 32007145
J Reprod Immunol. 2009 Dec;83(1-2):164-7
pubmed: 19836838
N Engl J Med. 2020 Apr 30;382(18):1708-1720
pubmed: 32109013
Eur Urol Focus. 2020 Sep 15;6(5):1124-1129
pubmed: 32563676
Fertil Steril. 2020 Jun;113(6):1135-1139
pubmed: 32482249
Fertil Steril. 2020 Aug;114(2):233-238
pubmed: 32650948
Viruses. 2020 Jan 24;12(2):
pubmed: 31991541
Fertil Steril. 2007 Oct;88(4):970.e1-7
pubmed: 17434502
JAMA. 2020 Aug 11;324(6):603-605
pubmed: 32644129
EClinicalMedicine. 2020 Nov;28:100604
pubmed: 33134901
J R Soc Med. 2006 Nov;99(11):573-5
pubmed: 17082302
Andrology. 2021 Jan;9(1):23-26
pubmed: 32453494
Microorganisms. 2020 Sep 28;8(10):
pubmed: 32998451
Cell. 2020 Apr 16;181(2):271-280.e8
pubmed: 32142651
Circ Res. 2020 May 8;126(10):1456-1474
pubmed: 32264791
Andrologia. 2018 Dec;50(11):e13140
pubmed: 30569651
Emerg Infect Dis. 2017 Nov;23(11):1922-1924
pubmed: 29048276
Hum Reprod Update. 2010 May-Jun;16(3):231-45
pubmed: 19934213
Cells. 2020 Apr 09;9(4):
pubmed: 32283711
J Med Virol. 2021 Jan;93(1):456-462
pubmed: 32621617
J Androl. 2000 Sep-Oct;21(5):739-46
pubmed: 10975421
Arab J Urol. 2018 Feb 13;16(1):10-20
pubmed: 29713532
Fertil Steril. 2020 Jul;114(1):33-43
pubmed: 32622411
Semin Cell Dev Biol. 1998 Aug;9(4):411-6
pubmed: 9813187
Nat Rev Immunol. 2020 Jun;20(6):351
pubmed: 32303698
Biol Reprod. 2018 Jul 1;99(1):101-111
pubmed: 29566165
Andrology. 2021 Jan;9(1):99-106
pubmed: 33150723
Sci China Life Sci. 2020 Jul;63(7):1006-1015
pubmed: 32361911
ERJ Open Res. 2021 Feb 08;7(1):
pubmed: 33575312
Fertil Steril. 1951 Nov-Dec;2(6):523-33
pubmed: 14887770
Biol Reprod. 2006 Feb;74(2):410-6
pubmed: 16237152
Natl Sci Rev. 2020 Sep;7(9):1414-1418
pubmed: 34192086