Candidate Biomarkers for the Prediction and Monitoring of Partial Remission in Pediatric Type 1 Diabetes.
autoimmunity
biomarkers
honeymoon
immune cell subpopulations
partial remission phase
pediatrics
prediction model
type 1 diabetes (T1D)
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2022
2022
Historique:
received:
30
11
2021
accepted:
31
01
2022
entrez:
14
3
2022
pubmed:
15
3
2022
medline:
3
5
2022
Statut:
epublish
Résumé
The partial remission (PR) phase, a period experienced by most patients with type 1 diabetes (T1D) soon after diagnosis, is characterized by low insulin requirements and improved glycemic control. Given the great potential of this phase as a therapeutic window for immunotherapies because of its association with immunoregulatory mechanisms and β-cell protection, our objective was to find peripheral immunological biomarkers for its better characterization, monitoring, and prediction. The longitudinal follow-up of 17 pediatric patients with new-onset T1D over one year revealed that, during the PR phase, remitter patients show increased percentages of effector memory (EM) T lymphocytes, terminally differentiated EM T lymphocytes, and neutrophils in comparison to non-remitter patients. On the contrary, remitter patients showed lower percentages of naïve T lymphocytes, regulatory T cells (T
Identifiants
pubmed: 35280980
doi: 10.3389/fimmu.2022.825426
pmc: PMC8904370
doi:
Substances chimiques
Biomarkers
0
Cytokines
0
Insulin
0
Interleukin-17
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
825426Informations de copyright
Copyright © 2022 Gomez-Muñoz, Perna-Barrull, Caroz-Armayones, Murillo, Rodriguez-Fernandez, Valls, Vazquez, Perez, Corripio, Castaño, Bel and Vives-Pi.
Déclaration de conflit d'intérêts
Unrelated to the work herein presented, MVP holds a patent that relates to immunotherapy for T1D and is co-founder of Ahead Therapeutics SL, and SRF is part-time employed at Ahead Therapeutics S.L. The other authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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