Functional Roles of Chemokine Receptor CCR2 and Its Ligands in Liver Disease.
CCL2
CCR2
PSMP
chemokine
hepatocellular carcinoma
macrophage
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2022
2022
Historique:
received:
10
11
2021
accepted:
08
02
2022
entrez:
14
3
2022
pubmed:
15
3
2022
medline:
3
5
2022
Statut:
epublish
Résumé
Chemokines are a family of cytokines that orchestrate the migration and positioning of immune cells within tissues and are critical for the function of the immune system. CCR2 participates in liver pathology, including acute liver injury, chronic hepatitis, fibrosis/cirrhosis, and tumor progression, by mediating the recruitment of immune cells to inflammation and tumor sites. Although a variety of chemokines have been well studied in various diseases, there is no comprehensive review presenting the roles of all known chemokine ligands of CCR2 (CCL2, CCL7, CCL8, CCL12, CCL13, CCL16, and PSMP) in liver disease, and this review aims to fill this gap. The introduction of each chemokine includes its discovery, its corresponding chemotactic receptors, physiological functions and roles in inflammation and tumors, and its impact on different immune cell subgroups.
Identifiants
pubmed: 35281057
doi: 10.3389/fimmu.2022.812431
pmc: PMC8913720
doi:
Substances chimiques
CCR2 protein, human
0
Chemokines
0
Ligands
0
Receptors, CCR2
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
812431Informations de copyright
Copyright © 2022 She, Ren, Chen, Wang, Chen, Wang and Chen.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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