Oral health conditions and COVID-19: A systematic review and meta-analysis of the current evidence.
Coronavirus
Dentistry
Oral diseases
Periodontitis
SARS-CoV-2
Journal
Aging and health research
ISSN: 2667-0321
Titre abrégé: Aging Health Res
Pays: Netherlands
ID NLM: 101772521
Informations de publication
Date de publication:
Mar 2022
Mar 2022
Historique:
received:
09
04
2021
revised:
25
02
2022
accepted:
02
03
2022
entrez:
14
3
2022
pubmed:
15
3
2022
medline:
15
3
2022
Statut:
ppublish
Résumé
The coronavirus disease 2019 (COVID-19) pandemic has highlighted the importance of understanding the underlying conditions that lead to COVID-19. Oral health has systemic implications in the maintenance of a healthy state. This study aimed to summarize evidence on the prevalence of oral health conditions in participants with COVID-19 and assess the associations between oral health conditions and COVID-19 related outcomes. Article searches were conducted in five databases and the gray literature from December 1, 2019 to March 1, 2021. Studies that reported oral health conditions for participants with COVID-19 and/or examined associations between oral health and COVID-19 were included. We identified 15 articles that encompassed 5,377 participants with COVID-19 from 10 countries. Dry mouth was the most common oral health condition reported (41.0%), followed by oral lesions (38.8%), orofacial pain (18.3%), and periodontal symptoms (11.7%). Based on the pooled odds ratios (ORs), periodontal symptoms were not associated with COVID-19 positivity (OR = 1.1; 95% confidence intervals [CI], 0.73-1.65) or mortality (OR = 2.71; 95% CI, 0.64-11.51), but were associated with COVID-19 severity (OR = 3.18; 95% CI, 1.81-5.58). Oral health conditions are common in participants with COVID-19 and should be considered in both the onset and progression of this disease. Knowledge in this area is still limited, and the quality of the data extracted was low. Further longitudinal studies are needed to ascertain whether oral health conditions are a consequence of infection with SARS-CoV-2 or whether they predate infection and are risk factors for COVID-19.
Sections du résumé
Background
UNASSIGNED
The coronavirus disease 2019 (COVID-19) pandemic has highlighted the importance of understanding the underlying conditions that lead to COVID-19. Oral health has systemic implications in the maintenance of a healthy state. This study aimed to summarize evidence on the prevalence of oral health conditions in participants with COVID-19 and assess the associations between oral health conditions and COVID-19 related outcomes.
Methods
UNASSIGNED
Article searches were conducted in five databases and the gray literature from December 1, 2019 to March 1, 2021. Studies that reported oral health conditions for participants with COVID-19 and/or examined associations between oral health and COVID-19 were included.
Results
UNASSIGNED
We identified 15 articles that encompassed 5,377 participants with COVID-19 from 10 countries. Dry mouth was the most common oral health condition reported (41.0%), followed by oral lesions (38.8%), orofacial pain (18.3%), and periodontal symptoms (11.7%). Based on the pooled odds ratios (ORs), periodontal symptoms were not associated with COVID-19 positivity (OR = 1.1; 95% confidence intervals [CI], 0.73-1.65) or mortality (OR = 2.71; 95% CI, 0.64-11.51), but were associated with COVID-19 severity (OR = 3.18; 95% CI, 1.81-5.58).
Conclusions
UNASSIGNED
Oral health conditions are common in participants with COVID-19 and should be considered in both the onset and progression of this disease. Knowledge in this area is still limited, and the quality of the data extracted was low. Further longitudinal studies are needed to ascertain whether oral health conditions are a consequence of infection with SARS-CoV-2 or whether they predate infection and are risk factors for COVID-19.
Identifiants
pubmed: 35281130
doi: 10.1016/j.ahr.2022.100064
pii: S2667-0321(22)00011-7
pmc: PMC8896863
doi:
Types de publication
Journal Article
Langues
eng
Pagination
100064Subventions
Organisme : NIDCR NIH HHS
ID : U01 DE027512
Pays : United States
Informations de copyright
© 2022 The Authors. Published by Elsevier B.V.
Déclaration de conflit d'intérêts
The authors declare that they have no financial interests or personal relationships that could influence the work reported in this study.
Références
J Dent Res. 2020 Jul;99(8):989
pubmed: 32271653
Eur J Epidemiol. 2010 Sep;25(9):603-5
pubmed: 20652370
Nat Rev Microbiol. 2021 Mar;19(3):155-170
pubmed: 33116300
Mil Med. 2001 Jan;166(1):85-9
pubmed: 11197106
Oral Dis. 2020 Mar;26(2):439-446
pubmed: 31715080
J Oral Microbiol. 2020 Nov 26;13(1):1848135
pubmed: 33391625
EClinicalMedicine. 2020 Jun 25;24:100434
pubmed: 32766543
J Clin Med. 2021 Feb 04;10(4):
pubmed: 33557130
Br Dent J. 2020 Jun;228(12):971-975
pubmed: 32591714
Lancet Respir Med. 2020 Jun;8(6):e46-e47
pubmed: 32353251
J Periodontol. 2005 Nov;76(11 Suppl):2154-60
pubmed: 16277588
Oral Sci Int. 2020 Sep 28;:
pubmed: 33041626
Int J Oral Sci. 2020 Feb 24;12(1):8
pubmed: 32094336
Br J Dermatol. 2021 Jan;184(1):184-185
pubmed: 32969503
Dent Med Probl. 2021 Jan-Mar;58(1):7-15
pubmed: 33666379
Br J Dermatol. 2020 Jul;183(1):71-77
pubmed: 32348545
J Dent Res. 2021 May;100(5):464-471
pubmed: 33655804
Protein Cell. 2018 May;9(5):488-500
pubmed: 29736705
J Am Dent Assoc. 2020 Jun;151(6):427-437
pubmed: 32450981
Lancet Microbe. 2020 May;1(1):e11
pubmed: 32835323
Rev Med Virol. 2021 Nov;31(6):e2226
pubmed: 33646645
Int J Infect Dis. 2020 Aug;97:326-328
pubmed: 32526392
Evid Based Med. 2017 Jun;22(3):85-87
pubmed: 28320705
PLoS Med. 2009 Jul 21;6(7):e1000097
pubmed: 19621072
Am J Otolaryngol. 2021 May-Jun;42(3):102905
pubmed: 33497914
Oral Dis. 2022 Apr;28 Suppl 1:991-993
pubmed: 32989904
Am J Otolaryngol. 2020 Nov - Dec;41(6):102721
pubmed: 32977063
J Am Med Dir Assoc. 2021 Oct;22(10):2039-2045
pubmed: 34579934
Intensive Care Med. 2020 Apr;46(4):586-590
pubmed: 32125455
J Clin Epidemiol. 1990;43(1):87-91
pubmed: 2319285
Life Sci. 2020 Oct 1;258:118166
pubmed: 32739471
Immunotherapy. 2016 Jul;8(8):959-70
pubmed: 27381687
Otolaryngol Head Neck Surg. 2020 Oct;163(4):722-728
pubmed: 32539587
Front Med (Lausanne). 2020 Nov 23;7:604980
pubmed: 33330570
Int Dent J. 2017 Sep;67 Suppl 2:7-13
pubmed: 29023743
Am J Otolaryngol. 2020 Sep - Oct;41(5):102612
pubmed: 32574896
Cochrane Database Syst Rev. 2019 Oct 3;10:ED000142
pubmed: 31643080
Br Dent J. 2021 Feb 24;:
pubmed: 33627848
J Clin Periodontol. 2021 Apr;48(4):483-491
pubmed: 33527378
Biomed Pharmacother. 2020 Sep;129:110337
pubmed: 32534226
J Clin Med. 2021 Feb 13;10(4):
pubmed: 33668602
Cell Prolif. 2020 Dec;53(12):e12923
pubmed: 33073910
Clin Case Rep. 2020 Nov 16;:
pubmed: 33362935
Clin Infect Dis. 2021 Dec 6;73(11):e4208-e4213
pubmed: 32173725
J Clin Med. 2020 Oct 07;9(10):
pubmed: 33036482
Nat Rev Immunol. 2020 Jun;20(6):363-374
pubmed: 32346093
J Dent Res. 2020 Sep;99(10):1120-1121
pubmed: 32479133
J Clin Periodontol. 2008 Aug;35(8):668-73
pubmed: 18564145
Nat Med. 2021 May;27(5):892-903
pubmed: 33767405