Signal-Induced Inhibition of Telomerase Activity in HL60 Cancer Cells by Signal Transduction Using the Biophysically Activated Regulative Molecule 31 (RM31): A Pilot Study.
biophysical activation
cancer cells
cell nucleus stimulation
htert
signal transduction
telomerase
Journal
Cureus
ISSN: 2168-8184
Titre abrégé: Cureus
Pays: United States
ID NLM: 101596737
Informations de publication
Date de publication:
Mar 2022
Mar 2022
Historique:
accepted:
08
03
2022
entrez:
14
3
2022
pubmed:
15
3
2022
medline:
15
3
2022
Statut:
epublish
Résumé
In this pilot study, we report the use of a novel, patented biophysical technology, which enables intranuclear access and cell nucleus stimulation, via the signal of the biophysically activated regulative molecule 31 (RM31). RM31 is the name of an isolated natural molecule found in the human body and is involved in many cellular mechanisms. We used a specific low electromagnetic field frequency to activate the RM31 molecule, which leads to specific signal transduction, to investigate the effect of telomerase activity in HL60 cancer cells. Our results revealed a dramatic inhibition in telomerase activity, a 99.5% decrease within 72 hours, with avoidance of subsequent reactivation, due to the simultaneous inhibition of human telomerase reverse transcriptase (hTERT).
Identifiants
pubmed: 35281585
doi: 10.7759/cureus.22962
pmc: PMC8906504
doi:
Types de publication
Journal Article
Langues
eng
Pagination
e22962Informations de copyright
Copyright © 2022, Klein et al.
Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
Références
Electromagn Biol Med. 2014 Sep;33(3):190-7
pubmed: 23781986
Cancer Lett. 2003 May 15;194(2):155-62
pubmed: 12757973
Cells. 2019 Jan 31;8(2):
pubmed: 30709063
Int J Mol Sci. 2017 Dec 21;19(1):
pubmed: 29267203
Methods Mol Biol. 2015;1238:3-25
pubmed: 25421652
Nat Protoc. 2006;1(3):1583-90
pubmed: 17406450
Oncol Lett. 2020 Aug;20(2):1015-1027
pubmed: 32724340
FEBS J. 2015 Feb;282(3):445-62
pubmed: 25429850
Int J Mol Sci. 2011;12(12):8661-94
pubmed: 22272098