Selective Serotonin Reuptake Inhibitor Pharmacokinetics During Pregnancy: Clinical and Research Implications.
SSRI (selective serotonergic reuptake inhibitors)
anxiety
depression
pharmacokinctics
pregnancy
Journal
Frontiers in pharmacology
ISSN: 1663-9812
Titre abrégé: Front Pharmacol
Pays: Switzerland
ID NLM: 101548923
Informations de publication
Date de publication:
2022
2022
Historique:
received:
10
12
2021
accepted:
24
01
2022
entrez:
14
3
2022
pubmed:
15
3
2022
medline:
15
3
2022
Statut:
epublish
Résumé
Pregnancy and associated physiologic changes affect the pharmacokinetics of many medications, including selective serotonin reuptake inhibitors-the first-line pharmacologic interventions for depressive and anxiety disorders. During pregnancy, SSRIs exhibit extensive pharmacokinetic variability that may influence their tolerability and efficacy. Specifically, compared to non-pregnant women, the activity of cytochrome P450 (CYP) enzymes that metabolize SSRIs drastically changes (e.g., decreased CYP2C19 activity and increased CYP2D6 activity). This perspective examines the impact of pharmacokinetic genes-related to CYP activity on SSRI pharmacokinetics during pregnancy. Through a simulation-based approach, plasma concentrations for SSRIs metabolized primarily by CYP2C19 (e.g., escitalopram) and CYP2D6 (e.g., fluoxetine) are examined and the implications for dosing and future research are discussed.
Identifiants
pubmed: 35281909
doi: 10.3389/fphar.2022.833217
pii: 833217
pmc: PMC8916222
doi:
Types de publication
Journal Article
Langues
eng
Pagination
833217Subventions
Organisme : NICHD NIH HHS
ID : R01 HD098757
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD099775
Pays : United States
Informations de copyright
Copyright © 2022 Poweleit, Cinibulk, Novotny, Wagner-Schuman, Ramsey and Strawn.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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