The Effects of Clofibrate on Neonatal Jaundice: A Systematic Review.

Clofibrate hyperbilirubinemia neonatal jaundice newborn jaundice

Journal

International journal of preventive medicine

ISSN: 2008-7802

Titre abrégé: Int J Prev Med

Pays: Iran

ID NLM: 101535380

Informations de publication

Date de publication:
2022

Historique:

received: 21 07 2020

accepted: 22 12 2020

entrez: 14 3 2022

pubmed: 15 3 2022

medline: 15 3 2022

Statut: epublish

Résumé

Neonatal jaundice is a prevalent disease that causes many complications, including kernicterus and even death. Previous studies have shown that clofibrate as an aryloxy isobutyric acid derivate can be effectively applied for the treatment of neonatal jaundice. Thus, this review was carried out to investigate the effects and mechanism of action of clofibrate on neonatal jaundice. The keywords such as "Clofibrate" in combination with "Neonatal jaundice" or "Neonatal hyperbilirubinemia" or "Newborn Jaundice" were used to search for relevant publications indexed in the Institute for Scientific Information (ISI), Scopus, PubMed, and Google Scholar databases. Finally, after reviewing the studies, 24 papers were included in this study. Results showed that the processes of albumin-bound bilirubin transfer to the hepatocytes, hepatic uptake, and storage via ligandin, hepatic conjugation via uridine diphosphate glucuronosyltransferase 1A1 (UGT1A1), conjugation into the bile via MRP2 represent the main action mechanism of clofibrate that turns it into the bilirubin conjugates and expels it from the bile. Besides, clofibrate has been shown to reduce the level of Total Serum Bilirubin (TSB) in infants even at a dosage of 25 mg/kg without leaving side effects. The results of this review revealed that clofibrate effectively reduces TSB in short-term usage and can even have a promising effect at the dosage of 25 mg/kg in full-term infants. Most studies have shown this property over a short period in term infants, and there is no evidence about long-term usage in this regard.

Sections du résumé

Background UNASSIGNED

Methods UNASSIGNED

The keywords such as "Clofibrate" in combination with "Neonatal jaundice" or "Neonatal hyperbilirubinemia" or "Newborn Jaundice" were used to search for relevant publications indexed in the Institute for Scientific Information (ISI), Scopus, PubMed, and Google Scholar databases. Finally, after reviewing the studies, 24 papers were included in this study.

Results UNASSIGNED

Results showed that the processes of albumin-bound bilirubin transfer to the hepatocytes, hepatic uptake, and storage via ligandin, hepatic conjugation via uridine diphosphate glucuronosyltransferase 1A1 (UGT1A1), conjugation into the bile via MRP2 represent the main action mechanism of clofibrate that turns it into the bilirubin conjugates and expels it from the bile. Besides, clofibrate has been shown to reduce the level of Total Serum Bilirubin (TSB) in infants even at a dosage of 25 mg/kg without leaving side effects.

Conclusions UNASSIGNED

The results of this review revealed that clofibrate effectively reduces TSB in short-term usage and can even have a promising effect at the dosage of 25 mg/kg in full-term infants. Most studies have shown this property over a short period in term infants, and there is no evidence about long-term usage in this regard.

Identifiants

DOI: 10.4103/ijpvm.IJPVM_407_20 PMID: 35281975 PMC: PMC8883667

pubmed: 35281975

doi: 10.4103/ijpvm.IJPVM_407_20

pii: IJPVM-13-3

pmc: PMC8883667

doi:

Types de publication

Journal Article Review

Langues

eng

Pagination

Informations de copyright

Déclaration de conflit d'intérêts

There are no conflicts of interest.

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