Sex-Differences in Aortic Stenosis: Mechanistic Insights and Clinical Implications.
aortic stenosis
extracellular matrix
remodeling
sex
valve interstitial cells
Journal
Frontiers in cardiovascular medicine
ISSN: 2297-055X
Titre abrégé: Front Cardiovasc Med
Pays: Switzerland
ID NLM: 101653388
Informations de publication
Date de publication:
2022
2022
Historique:
received:
19
11
2021
accepted:
31
01
2022
entrez:
14
3
2022
pubmed:
15
3
2022
medline:
15
3
2022
Statut:
epublish
Résumé
We aim to analyse sex-specific differences in aortic valves (AVs) and valve interstitial cells (VICs) from aortic stenosis (AS) patients. 238 patients with severe AS undergoing surgical valve replacement were recruited. Two hundred and two AVs (39.1% women) were used for Our results suggest that the mechanisms driving the pathogenesis of AS could be different in men and women. Male AVs and isolated VICs presented more inflammation, oxidative stress, ECM remodeling and calcification as compared to those from women. A better knowledge of the pathophysiological pathways in AVs and VICs will allow the development of sex-specific options for the treatment of AS.
Identifiants
pubmed: 35282345
doi: 10.3389/fcvm.2022.818371
pmc: PMC8907577
doi:
Types de publication
Journal Article
Langues
eng
Pagination
818371Informations de copyright
Copyright © 2022 Matilla, Garaikoetxea, Arrieta, García-Peña, Fernández-Celis, Navarro, Gainza, Álvarez, Sádaba, Jover and López-Andrés.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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