The effects of gender-affirming hormone therapy on cardiovascular and skeletal health: A literature review.

Bone mineral density Cardiometabolic Gender-affirming hormone therapy Trabecular bone score Transgender

Journal

Metabolism open
ISSN: 2589-9368
Titre abrégé: Metabol Open
Pays: England
ID NLM: 101767753

Informations de publication

Date de publication:
Mar 2022
Historique:
received: 13 01 2022
revised: 23 02 2022
accepted: 01 03 2022
entrez: 14 3 2022
pubmed: 15 3 2022
medline: 15 3 2022
Statut: epublish

Résumé

Approximately 1.5 million people in the United States currently identify as transgender. The use of gender affirming hormone therapy is integral to routine clinical care of transgender individuals, yet our understanding of the effects of this therapy is limited. There are reasons to believe that gender affirming hormone therapy may have important effects on cardiovascular risk and bone health in transgender individuals. The purpose of this review article is to summarize the evidence for the cardiovascular effects (including coronary artery disease, hypertension and stroke) as well as the effects on bone metabolism associated with gender affirming hormone therapy in both transgender men and transgender women.

Identifiants

pubmed: 35282421
doi: 10.1016/j.metop.2022.100173
pii: S2589-9368(22)00011-1
pmc: PMC8907681
doi:

Types de publication

Journal Article Review

Langues

eng

Pagination

100173

Informations de copyright

© 2022 The Authors. Published by Elsevier Inc.

Déclaration de conflit d'intérêts

The authors disclose no conflict of interest related to this manuscript. This work was supported by the Empire Clinical Research Investigator Program (ECRIP) from the 10.13039/100004856New York State Department of Health.

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Auteurs

Nyein Chan Swe (N)

Department of Cardiology, Cardiovascular Prevention, Lenox Hill Hospital, 110 East 59th Street, Suite 8A, New York, NY, 10022, USA.

Samihah Ahmed (S)

Division of Endocrinology, Lenox Hill Hospital, 110 East 59th Street, Suite 8B, New York, NY, 10022, USA.

Marwen Eid (M)

Department of Cardiology, Cardiovascular Prevention, Lenox Hill Hospital, 110 East 59th Street, Suite 8A, New York, NY, 10022, USA.

Leonid Poretsky (L)

Department of Medicine, Lenox Hill Hospital, 110 East 59th Street, Suite 8B, New York, NY, 10022, USA.
Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, 110 East 59th Street, Suite 8B, New York, NY, 10022, USA.
Feinstein Institutes for Medical Research, 110 East 59th Street, Suite 8B, New York, NY, 10022, USA.

Eugenia Gianos (E)

Zucker School and Medicine, 110 East 59th Street, Suite 8A, New York, NY, 10022, USA.
Cardiovascular Prevention, Northwell Health, 110 East 59th Street, Suite 8A, New York, NY, 10022, USA.
Western Region, Katz Institute Women's Heart Program, 110 East 59th Street, Suite 8A, New York, NY, 10022, USA.
Women's Heart Program, Lenox Hill Hospital, 110 East 59th Street, Suite 8A, New York, NY, 10022, USA.

Natalie E Cusano (NE)

Zucker School of Medicine at Hofstra/Northwell, 110 East 59th Street, Suite 8B, New York, NY, 10022, USA.
Bone Metabolism Program, Lenox Hill Hospital, 110 East 59th Street, Suite 8B, New York, NY, 10022, USA.
Division of Endocrinology, Lenox Hill Hospital, 110 East 59th Street, Suite 8B, New York, NY, 10022, USA.

Classifications MeSH